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      Neutrophil Extracellular Traps Kill Bacteria

      Science
      American Association for the Advancement of Science (AAAS)

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          Abstract

          Neutrophils engulf and kill bacteria when their antimicrobial granules fuse with the phagosome. Here, we describe that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria. These neutrophil extracellular traps (NETs) degrade virulence factors and kill bacteria. NETs are abundant in vivo in experimental dysentery and spontaneous human appendicitis, two examples of acute inflammation. NETs appear to be a form of innate response that binds microorganisms, prevents them from spreading, and ensures a high local concentration of antimicrobial agents to degrade virulence factors and kill bacteria.

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          Author and article information

          Journal
          Science
          Science
          American Association for the Advancement of Science (AAAS)
          0036-8075
          1095-9203
          March 05 2004
          March 05 2004
          : 303
          : 5663
          : 1532-1535
          Article
          10.1126/science.1092385
          15001782
          e956a4a3-c862-49de-a89d-41649b5e3bfe
          © 2004
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