G-quadruplex oligonucleotide AS1411 as a cancer-targeting agent: Uses and mechanisms.

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Abstract

AS1411 is a 26-mer G-rich DNA oligonucleotide that forms a variety of G-quadruplex structures. It was identified based on its cancer-selective antiproliferative activity and subsequently determined to be an aptamer to nucleolin, a multifunctional protein that preferentially binds quadruplex nucleic acids and which is present at high levels on the surface of cancer cells. AS1411 has exceptionally efficient cellular internalization compared to non-quadruplex DNA sequences.

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Author and article information

Journal

Journal ID (iso-abbrev): Biochim. Biophys. Acta

Title: Biochimica et biophysica acta

Publisher: Elsevier BV

ISSN: 0006-3002

ISSN (Print): 0006-3002

Publication date (Electronic): May 2017

Volume: 1861

Issue: 5 Pt B

Affiliations

[1 ] Department of Medicine, University of Louisville, USA; James Graham Brown Cancer Center, University of Louisville, USA. Electronic address: paula.bates@louisville.edu.

[2 ] Department of Medicine, University of Arizona, USA.

[3 ] Department of Medicine, University of Louisville, USA; James Graham Brown Cancer Center, University of Louisville, USA.

[4 ] Department of Biomedical Engineering, University of Louisville, USA.

Article

Publisher Item ID: S0304-4165(16)30509-8

DOI: 10.1016/j.bbagen.2016.12.015

PubMed ID: 28007579

SO-VID: e8df881c-fef0-49a9-a86a-1cec47a06ab0

History

Keywords: AS1411,Aptamer,Cancer,Contrast agent,Drug delivery,Imaging,Nanoparticles,Nucleolin,Quadruplex,Radiosensitizer

Data availability:

Keywords: AS1411, Aptamer, Cancer, Contrast agent, Drug delivery, Imaging, Nanoparticles, Nucleolin, Quadruplex, Radiosensitizer

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