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      Prospects for Additive Manufacturing in Contact Lens Devices

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          Abstract

          Additive manufacturing (3D printing) has the ability to architect structures at microscale, giving rise to the development of functional contact lenses (CLs) with inbuilt sensing capabilities. 3D printing technology enables fabrication of CLs without surface geometry restrictions. Spherical, nonspherical, symmetric, and asymmetric lenses can be manufactured in an integrated production process. Advantages of 3D printing over conventional techniques include fast and easy production, one‐step manufacturing, and no post processing such as grinding or polishing. In addition, and most significantly, 3D printing can create chambers within the wall of the lenses by taking the advantage of computer‐aided modeling and layer‐by‐layer deposition of the materials. These inbuilt chambers can be used for loading drugs and sensing elements. The computer‐aided design modeling can allow for manufacturing of patient‐specific CLs. This article focuses on the 3D‐printing approaches and the challenges faced in fabricating CLs. 3D‐printing technology as a technique for manufacturing of CLs is discussed, in addition to the manufacturing challenges and the possible solutions to overcome the obstacles.

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          Additive manufacturing (3D printing): A review of materials, methods, applications and challenges

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            Direct Ink Writing of 3D Functional Materials

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              Is Open Access

              Recent advances in 3D printing of biomaterials

              3D Printing promises to produce complex biomedical devices according to computer design using patient-specific anatomical data. Since its initial use as pre-surgical visualization models and tooling molds, 3D Printing has slowly evolved to create one-of-a-kind devices, implants, scaffolds for tissue engineering, diagnostic platforms, and drug delivery systems. Fueled by the recent explosion in public interest and access to affordable printers, there is renewed interest to combine stem cells with custom 3D scaffolds for personalized regenerative medicine. Before 3D Printing can be used routinely for the regeneration of complex tissues (e.g. bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g. liver, lymphoid organs), several technological limitations must be addressed. In this review, the major materials and technology advances within the last five years for each of the common 3D Printing technologies (Three Dimensional Printing, Fused Deposition Modeling, Selective Laser Sintering, Stereolithography, and 3D Plotting/Direct-Write/Bioprinting) are described. Examples are highlighted to illustrate progress of each technology in tissue engineering, and key limitations are identified to motivate future research and advance this fascinating field of advanced manufacturing.
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                Author and article information

                Contributors
                (View ORCID Profile)
                Journal
                Advanced Engineering Materials
                Adv Eng Mater
                Wiley
                1438-1656
                1527-2648
                January 2021
                October 2020
                January 2021
                : 23
                : 1
                Affiliations
                [1 ] Department of Mechanical Engineering Khalifa University of Science and Technology 127788 Abu Dhabi United Arab Emirates
                [2 ] Department of Chemical Engineering Imperial College London London SW7 2AZ UK
                [3 ] Department of Bio and Brain Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea
                [4 ] KAIST Institute for Health Science and Technology (KIHST) Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea
                Article
                10.1002/adem.202000941
                e6a799e2-5e23-4502-b3c7-3f6e78825f04
                © 2021

                http://onlinelibrary.wiley.com/termsAndConditions#vor

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