Quantitation of HBV cccDNA in anti-HBc-positive liver donors by droplet digital PCR: A new tool to detect occult infection.

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Abstract

The accurate diagnosis of occult hepatitis B virus (HBV) infection (OBI) requires the demonstration of HBV DNA in liver biopsies of hepatitis B surface antigen-negative individuals. However, in clinical practice a latent OBI is deduced by the finding of the antibody to the hepatitis B core antigen (anti-HBc). We investigated the true prevalence of OBI and the molecular features of intrahepatic HBV in anti-HBc-positive individuals.

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Journal

Journal ID (iso-abbrev): J. Hepatol.

Title: Journal of hepatology

Publisher: Elsevier BV

ISSN (Electronic): 1600-0641

ISSN (Print): 0168-8278

Publication date (Electronic): Aug 2018

Volume: 69

Issue: 2

Affiliations

[1 ] Department of Medical Sciences, University of Turin, Gastroenterology Division of Città della Salute e della Scienza of Turin, University Hospital, Turin, Italy. Electronic address: gianpaolo.caviglia@unito.it.

[2 ] Department of Medical Sciences, University of Turin, Gastroenterology Division of Città della Salute e della Scienza of Turin, University Hospital, Turin, Italy.

[3 ] General Surgery 2U, Liver Transplant Center - A.O.U. Città della Salute e della Scienza di Torino, Molinette Hospital, Department of Surgical Sciences, University of Turin, Turin, Italy.

[4 ] Regional Transplant Center, Piedmont, A.O.U. Città della Salute e della Scienza di Torino, Molinette Hospital, Turin, Italy.

Article

Publisher Item ID: S0168-8278(18)31963-9

DOI: 10.1016/j.jhep.2018.03.021

PubMed ID: 29621551

SO-VID: e55c360c-f4f3-4a5c-bde0-79bfe449723f

History

Keywords: Digital droplet PCR,Anti-HBc,HBcrAg,Hepatitis B virus,Occult HBV infection

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Keywords: Digital droplet PCR, Anti-HBc, HBcrAg, Hepatitis B virus, Occult HBV infection

Quantitation of HBV cccDNA in anti-HBc-positive liver donors by droplet digital PCR: A new tool to detect occult infection.

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Decoding Infection and Transmission

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