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RGG Repeats of PrP-like Shadoo Protein Bind Nucleic Acids
November 02 2012
November 02 2012
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Abstract
<p class="first" id="d5755235e71">Shadoo (Sho) is a central nervous system glycoprotein
with characteristics similar
to those of the cellular prion protein PrP(C), each containing a highly conserved
hydrophobic domain (HD) and an N-terminal repeat region. Whereas PrP(C) includes histidine-containing
octarepeats, the Sho region N-terminal to the HD includes tandem positively charged
"RGG boxes", predicted to bind RNA. Here, we demonstrate that Sho binds DNA and RNA
in vitro via this arginine-rich region.
</p>