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Sugar for the brain: the role of glucose in physiological and pathological brain function
Author(s):
Philipp Mergenthaler
,
Ute Lindauer
,
Gerald A. Dienel
,
Andreas Meisel
Publication date
Created:
October 2013
Publication date
(Print):
October 2013
Journal:
Trends in Neurosciences
Publisher:
Elsevier BV
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There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
The mammalian brain depends upon glucose as its main source of energy, and tight regulation of glucose metabolism is critical for brain physiology. Consistent with its critical role for physiological brain function, disruption of normal glucose metabolism as well as its interdependence with cell death pathways forms the pathophysiological basis for many brain disorders. Here, we review recent advances in understanding how glucose metabolism sustains basic brain physiology. We synthesize these findings to form a comprehensive picture of the cooperation required between different systems and cell types, and the specific breakdowns in this cooperation that lead to disease. Copyright © 2013 Elsevier Ltd. All rights reserved.
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Author and article information
Journal
Title:
Trends in Neurosciences
Abbreviated Title:
Trends in Neurosciences
Publisher:
Elsevier BV
ISSN (Print):
01662236
Publication date Created:
October 2013
Publication date (Print):
October 2013
Volume
: 36
Issue
: 10
Pages
: 587-597
Article
DOI:
10.1016/j.tins.2013.07.001
PMC ID:
3900881
PubMed ID:
23968694
SO-VID:
e4f0e066-f8e2-48ef-8832-835cda4a6e24
Copyright ©
© 2013
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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