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      • Record: found
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      Health-related quality of life and its related factors in patients with systemic lupus erythematosus in southwest Iran: a cross-sectional study

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          Abstract

          Background

          Quality of life (QoL) is an important measure in health assessment. It is impacted by unclear factors in Systemic Lupus Erythematosus (SLE) patients. The study aimed to investigate the factors related to QoL in SLE patients.

          Methods

          This cross-sectional study was performed on 140 (136 women and four men) Iranian SLE patients of Hafiz Hospital from June 2019 to August 2020. The Lupus Erythematosus Quality of Life Questionnaire (LEQoL) was used to evaluate the quality of life. The patients were evaluated with this questionnaire for four weeks in eight dimensions health, emotional health, body image, pain, planning, intimate relationships, and the burden of others. Related factors of LEQoL were evaluated using multivariable linear regression.

          Results

          The mean age was 34.09(8.96) years. The total mean QoL Score was 65.5 ± 22.4. The multivariable analysis showed that duration of disease (β:-1.12, 95% CI:-1.44 to -0.79, P:0.001), physical activity(β:-12.99, 95% CI:-19.2 to -6.13, P:0.001), kidney involvement (β:-9.2, 95% CI:-16.61 to -2.79, P:0.03) and skin involvement(β:-8.7, 95% CI:-17.2 to -0.2, P:0.031) were significantly related to the total mean QOL score of SLE patients.

          Conclusion

          The QoL of Iranian patients with SLE was low. Age and gender can be related to the decrease in the QoL of patients with SLE. Increasing the disease duration, physical activity, kidney involvement, and skin involvement can be related to the decrease in the QOL of Iranian patients with SLE.

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          Most cited references24

          • Record: found
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          Derivation of the sledai. A disease activity index for lupus patients

          David Sackett, Claire Bombardier, Dafna D. Gladman … (1992)
          Article 0 comments Cited 191 times – based on 0 reviews     Review now
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            Development and validation of a disease-specific health-related quality of life measure, the LupusQol, for adults with systemic lupus erythematosus.

            Kathleen McElhone, Janice Abbott, Joanna Shelmerdine … (2007)
            To develop and validate a disease-specific health-related quality of life (HRQOL) instrument for adults with systemic lupus erythematosus (SLE). The work consisted of 6 stages. Stage 1 included item generation for questionnaire content from semistructured interviews with SLE patients. In stage 2 item selection for the draft questionnaire was performed by thematic analysis of the patient interview transcripts and expert panel agreement. In stage 3 the content validity of the draft questionnaire was assessed by patients completing the questionnaire and providing critical feedback. In stages 4 and 5 construct validity and internal reliability of the 3 versions of the LupusQoL were evaluated using principal component analysis with varimax rotation and Cronbach's alpha coefficients, respectively. In stage 6 discriminatory validity, concurrent validity, and test-retest reliability were evaluated. Stages 1, 2, and 3 resulted in a preliminary instrument containing 63 items. In stage 4, 8 domains were identified. This factor structure, accounting for 82% of the variance, was confirmed in stage 5. The domains and Cronbach's alpha coefficients were physical health (0.94), emotional health (0.94), body image (0.89), pain (0.92), planning (0.93), fatigue (0.88), intimate relationships (0.96), and burden to others (0.94). Discriminant validity was demonstrated for different levels of disease activity (British Isles Lupus Assessment Group Index) and damage (Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index). High correlations (r = 0.71-0.79) between comparable domains of the Short Form 36 and the LupusQoL assured acceptable concurrent validity. Good test-retest reliability (r = 0.72-0.93) was demonstrated. The LupusQoL is a validated SLE-specific HRQOL instrument with 34 items across 8 domains defined by patients as being important.
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              Employment and work disability in systemic lupus erythematosus: a systematic review.

              Janet Pope, Kim Baker (2009)
              Many studies have provided information on employment and work disability (WD) rates in patients with SLE, yet are often limited by small sample sizes, poor generalizability or fail to examine the risks and outcomes of WD. Our objective was to systematically review the literature on WD in SLE to identify a more generalizable point estimate and range of WD in SLE patients. A search was conducted using Medline, EMBase, PubMed and Cochrane databases to identify publications related to SLE and employment and/or WD. Characteristics of the study samples and employment/WD data were extracted. Descriptive statistics, a test for heterogeneity and random effects models were performed to obtain pooled estimates of employment and WD rates for all patients. Twenty-six studies with a total of 9886 SLE patients were found; however, not all patients were reviewed for WD. Larger studies demonstrated the prevalence of WD at 20-40%, and pooled estimates found that 46% (95% CI 40%, 52%) were employed with SLE and 34% (95% CI 24%, 44%) had WD. WD was related to psychosocial and disease-related factors including age, race, socioeconomic status (SES), education, disease activity and duration, pain, fatigue, anxiety and neurocognitive involvement. This study provides strong evidence that costs of SLE may be very high due to job loss at a younger age in SLE patients, and identifies some risk factors associated with WD, which should be targeted by interventions aimed at preventing job loss.
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                Author and article information

                Contributors
                Sakineh Hashemi: Sakihashemi@yahoo.com
                Sahar Farahbakhsh: Farahbsahar@gmail.com
                Zahra Aghakhani: Zahra_aghakhani@yahoo.com
                Ali MomayezanMarnani: ali1momayezan@gmail.com
                Nazi Hemati: Nazihe2014@gmail.com
                Somayeh Hashemi: Saha_ha33@yahoo.com
                Journal
                Journal ID (nlm-ta): BMC Psychol
                Journal ID (iso-abbrev): BMC Psychol
                Title: BMC Psychology
                Publisher: BioMed Central (London )
                ISSN (Electronic): 2050-7283
                Publication date (Electronic): 1 September 2023
                Publication date PMC-release: 1 September 2023
                Publication date Collection: 2023
                Volume: 11
                Electronic Location Identifier: 259
                Affiliations
                [1 ]GRID grid.412571.4, ISNI 0000 0000 8819 4698, Internal Medicine, , Shiraz University of Medical Sciences, ; Shiraz, Iran
                [2 ]GRID grid.469309.1, ISNI 0000 0004 0612 8427, Occupational Therapy, , Zanjan University of Medical Sciences, ; Zanjan, Iran
                [3 ]GRID grid.21100.32, ISNI 0000 0004 1936 9430, Science, , York University, ; Toronto, Canada
                [4 ]GRID grid.411036.1, ISNI 0000 0001 1498 685X, Nursing, , Isfahan University of Medical Sciences, ; Isfahan, Iran
                [5 ]GRID grid.412573.6, ISNI 0000 0001 0745 1259, Clinical Exercise Physiology, , Shiraz University, ; Shiraz, Iran
                Article
                Publisher ID: 1300
                DOI: 10.1186/s40359-023-01300-5
                PMC ID: 10472603
                PubMed ID: 37658385
                SO-VID: e46aa396-a3cd-413b-8323-9bfdf628ac03
                Copyright © © BioMed Central Ltd., part of Springer Nature 2023
                License:

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                Date received : 26 March 2023
                Date accepted : 23 August 2023
                Categories
                Subject: Research
                Custom metadata
                issue-copyright-statement © BioMed Central Ltd., part of Springer Nature 2023

                Keywords: quality of life,systemic lupus erythematosus,iranian people
                Data availability:
                Keywords: quality of life, systemic lupus erythematosus, iranian people

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