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      Machine learning annotation of human branchpoints.

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          Abstract

          The branchpoint element is required for the first lariat-forming reaction in splicing. However current catalogues of human branchpoints remain incomplete due to the difficulty in experimentally identifying these splicing elements. To address this limitation, we have developed a machine-learning algorithm-branchpointer-to identify branchpoint elements solely from gene annotations and genomic sequence.

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          Author and article information

          Journal
          Bioinformatics
          Bioinformatics (Oxford, England)
          Oxford University Press (OUP)
          1367-4811
          1367-4803
          Mar 15 2018
          : 34
          : 6
          Affiliations
          [1 ] Genomics and Epigenetics, Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.
          [2 ] St Vincent's Clinical School, University of New South Wales, Sydney, NSW 2052, Australia.
          [3 ] Altius Institute for Biomedical Sciences, Seattle, WA 98121, USA.
          Article
          4575139
          10.1093/bioinformatics/btx688
          29092009
          e3ab6319-5ff8-4f55-8bb5-3d5afd01d763
          History

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