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Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: randomized clinical trial.
Pierluigi Benedetti Panici
1 ,
Stefano Basile ,
Francesco Maneschi ,
Andrea Alberto Lissoni ,
Mauro Signorelli ,
Giovanni Scambia ,
Roberto Angioli ,
Saverio Tateo ,
Giorgia Mangili ,
Dionyssios Katsaros ,
Gaetano Garozzo ,
Elio Campagnutta ,
Nicoletta Donadello ,
Stefano Greggi ,
Mauro Melpignano ,
Francesco Raspagliesi ,
Nicola Ragni ,
Gennaro Cormio ,
Roberto Grassi ,
Massimo Franchi ,
Diana Giannarelli ,
Roldano Fossati ,
Valter Torri ,
Mariangela Amoroso ,
Clara Crocè ,
Costantino Mangioni
Dec 03 2008
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Abstract
Pelvic lymph nodes are the most common site of extrauterine tumor spread in early-stage endometrial cancer, but the clinical impact of lymphadenectomy has not been addressed in randomized studies. We conducted a randomized clinical trial to determine whether the addition of pelvic systematic lymphadenectomy to standard hysterectomy with bilateral salpingo-oophorectomy improves overall and disease-free survival.