0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Status, implications and challenges of European safe and sustainable by design paradigms applicable to nanomaterials and advanced materials

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Current European (EU) policies, such as the Green Deal, envisage safe and sustainable by design (SSbD) practices for the management of chemicals, which cogently entail nanomaterials (NMs) and advanced materials (AdMa).

          Abstract

          Current European (EU) policies, such as the Green Deal, envisage safe and sustainable by design (SSbD) practices for the management of chemicals, which cogently entail nanomaterials (NMs) and advanced materials (AdMa). These practices, applied at the earliest stages of innovation and throughout the life-cycle of chemicals, materials and products, could prevent and/or minimise their environmental, health and safety (EHS) and sustainability impacts. This requires a shift from the established risk control paradigms towards prevention-based approaches at the design stage that accelerate the development of safer and more sustainable chemicals, materials, products and processes, while promoting a transition towards a circular economy and a more sustainable future. The EU commission has funded several Horizon 2020 projects applying the concepts of SSbD to nanotechnologies, biotechnologies and advanced materials. This article is inspired from the answers and opinions shared during a stakeholders meeting arranged throughout the workshop entitled ‘ Safe and Sustainable by Design Paradigms applied to NMs and AdMa’, held in Venice, Italy, in September 2022. The goal of the workshop was to identify differences and overlaps between the SSbD approaches and to provide common messages on the progress towards the implementation of concrete SSbD concepts, and to reveal challenges faced in their realistic and straightforward execution. In this article, we provide insights into the intersecting industrial domains, the technical and organisational challenges to the practical implementation of the SSbD, and future financial directions in supporting and maintaining the digital products currently under development within the H2020 projects, in order to ultimately enable their uptake by industry and regulators.

          Related collections

          Most cited references43

          • Record: found
          • Abstract: found
          • Article: found
          Is Open Access

          Informing Selection of Nanomaterial Concentrations for ToxCast in Vitro Testing Based on Occupational Exposure Potential

          Background: Little justification is generally provided for selection of in vitro assay testing concentrations for engineered nanomaterials (ENMs). Selection of concentration levels for hazard evaluation based on real-world exposure scenarios is desirable. Objectives: Our goal was to use estimates of lung deposition after occupational exposure to nanomaterials to recommend in vitro testing concentrations for the U.S. Environmental Protection Agency’s ToxCast™ program. Here, we provide testing concentrations for carbon nanotubes (CNTs) and titanium dioxide (TiO2) and silver (Ag) nanoparticles (NPs). Methods: We reviewed published ENM concentrations measured in air in manufacturing and R&D (research and development) laboratories to identify input levels for estimating ENM mass retained in the human lung using the multiple-path particle dosimetry (MPPD) model. Model input parameters were individually varied to estimate alveolar mass retained for different particle sizes (5–1,000 nm), aerosol concentrations (0.1 and 1 mg/m3), aspect ratios (2, 4, 10, and 167), and exposure durations (24 hr and a working lifetime). The calculated lung surface concentrations were then converted to in vitro solution concentrations. Results: Modeled alveolar mass retained after 24 hr is most affected by activity level and aerosol concentration. Alveolar retention for Ag and TiO2 NPs and CNTs for a working-lifetime (45 years) exposure duration is similar to high-end concentrations (~ 30–400 μg/mL) typical of in vitro testing reported in the literature. Conclusions: Analyses performed are generally applicable for providing ENM testing concentrations for in vitro hazard screening studies, although further research is needed to improve the approach. Understanding the relationship between potential real-world exposures and in vitro test concentrations will facilitate interpretation of toxicological results.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Towards FAIR nanosafety data

              Bookmark
              • Record: found
              • Abstract: found
              • Article: found
              Is Open Access

              Towards safe and sustainable innovation in nanotechnology: State-of-play for smart nanomaterials

              The European Green Deal, the European Commission's new Action Plan for a Circular Economy, the new European Industrial Strategy and the Chemicals Strategy for Sustainability launched in October 2020 are ambitious plans to achieve a sustainable, fair and inclusive European Union's economy. In line with the United Nations Sustainable Development Goals 2030, these policies require that any new material or product should be not only functional and cost-effective but also safe and sustainable to ensure compliance with regulation and acceptance by consumers. Nanotechnology is one of the technologies that could enable such a green growth. This paper focuses on advanced nanomaterials that actively respond to external stimuli, also known as ‘smart nanomaterials’, and which are already on the market or in the research and development phase for non-medical applications such as in agriculture, food, food packaging and cosmetics. A review shows that smart nanomaterials and enabled products may present new challenges for safety and sustainability assessment due to their complexity and dynamic behaviour. Moreover, existing regulatory frameworks, in particular in the European Union, are probably not fully prepared to address them. What is missing today is a systematic and comprehensive approach that allows for considering sustainability aspects hand in hand with safety considerations very early on at the material design stage. We call on innovators, scientists and authorities to further develop and promote the ‘Safe- and Sustainable-by-Design’ concept in nanotechnology and propose some initiatives to go into this direction.
                Bookmark

                Author and article information

                Contributors
                (View ORCID Profile)
                (View ORCID Profile)
                (View ORCID Profile)
                (View ORCID Profile)
                (View ORCID Profile)
                (View ORCID Profile)
                (View ORCID Profile)
                Journal
                RSSUAN
                RSC Sustainability
                RSC Sustain.
                Royal Society of Chemistry (RSC)
                2753-8125
                March 09 2023
                2023
                : 1
                : 2
                : 234-250
                Affiliations
                [1 ]Transgero Ltd, Newcastlewest, V42V384 Limerick, Ireland
                [2 ]Dept. of Accounting and Finance, Kemmy Business School, University of Limerick, Ireland, V94PH93
                [3 ]Istituto di Scienza e Tecnologia dei Materiali Ceramici (CNR-ISTEC), Via Granarolo, 64, 48018 Faenza, RA, Italy
                [4 ]LEITAT Technological Center, C/ de la Innovació 2, 08225 Terrassa, Barcelona, Spain
                [5 ]ITENE Research Center, C/Albert Einstein 1, 46980 Paterna, Valencia, Spain
                [6 ]EMERGE Ltd, Sofia, Bulgaria
                [7 ]International Research Centre in Critical Raw Materials-ICCRAM, University of Burgos, Plaza Misael Bañuelos s/n, 09001, Burgos, Spain
                [8 ]BioNanoNet Forschungsgesellschaft mbH, Kaiser-Josef-Platz 9, 8010 Graz, Austria
                [9 ]Rina Consulting SpA, viale Cesare Pavese 305, 00144 Rome, Italy
                [10 ]AcumenIST SRL, Rue Fétis 19, 1040 Etterbeek, Belgium
                [11 ]School of Geography, Earth and Environmental Sciences, University of Birmingham, Edgbaston, B15 2TT Birmingham, UK
                [12 ]Instituto Nacional de Seguridad y Salud (INSST), Centro Nacional de Verificación de Maquinaria, Camino de la Dinamita s/n, 48903, Barakaldo, Spain
                [13 ]European Commission, Joint Research Centre (JRC), Ispra, Italy
                Article
                10.1039/D2SU00101B
                e15af991-b288-40cd-b7e5-fc891074eefa
                © 2023

                http://creativecommons.org/licenses/by-nc/3.0/

                History

                Comments

                Comment on this article