Contributors
Davina Gale:
ORCID: http://orcid.org/0000-0002-4521-8199
Role: ConceptualizationRole: Data curationRole: InvestigationRole: MethodologyRole:
Project administrationRole: SupervisionRole: ValidationRole: Writing – original draftRole:
Writing – review & editing
Andrew R. J. Lawson: Role: ConceptualizationRole: Data curationRole: InvestigationRole: MethodologyRole:
ValidationRole: Writing – review & editing
Karen Howarth: Role: InvestigationRole: ValidationRole: Writing – review & editing
Mikidache Madi: Role: Investigation
Bradley Durham: Role: Investigation
Sarah Smalley: Role: InvestigationRole: MethodologyRole: Validation
John Calaway: Role: InvestigationRole: Validation
Shannon Blais: Role: InvestigationRole: Validation
Greg Jones: Role: Supervision
James Clark: Role: Supervision
Peter Dimitrov: Role: Formal analysis
Michelle Pugh: Role: ValidationRole: Writing – review & editing
Samuel Woodhouse: Role: InvestigationRole: Writing – review & editing
Michael Epstein: Role: Data curationRole: Formal analysis
Ana Fernandez-Gonzalez: Role: InvestigationRole: Methodology
Alexandra S. Whale: Role: InvestigationRole: Methodology
Jim F. Huggett: Role: Supervision
Carole A. Foy: Role: Funding acquisitionRole: SupervisionRole: Writing – review & editing
Gerwyn M. Jones: Role: Investigation
Hadas Raveh-Amit: Role: Resources
Karin Schmitt: Role: Funding acquisitionRole: Project administrationRole: Resources
Alison Devonshire: Role: InvestigationRole: MethodologyRole: Project administrationRole: VisualizationRole:
Writing – review & editing
Emma Green: Role: ValidationRole: Writing – review & editing
Tim Forshew: Role: ConceptualizationRole: Data curationRole: MethodologyRole: SupervisionRole:
ValidationRole: Writing – review & editing
Vincent Plagnol: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: MethodologyRole:
SoftwareRole: SupervisionRole: ValidationRole: Writing – review & editing
Nitzan Rosenfeld: Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: SupervisionRole:
Writing – review & editing
Alvaro Galli: Role: Editor
Journal
Journal ID (nlm-ta): PLoS One
Journal ID (iso-abbrev): PLoS ONE
Journal ID (publisher-id): plos
Journal ID (pmc): plosone
Title:
PLoS ONE
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Electronic):
1932-6203
Publication date
(Electronic):
16
March
2018
Publication date Collection: 2018
Volume: 13
Issue: 3
Electronic Location Identifier: e0194630
Affiliations
[1
]
Inivata Ltd, Granta Park, Cambridge, United Kingdom
[2
]
Inivata Inc, Research Triangle Park, NC, United States of America
[3
]
LGC, Teddington, Middlesex, United Kingdom
[4
]
School of Biosciences & Medicine, Faculty of Health & Medical Science, University
of Surrey, Guildford, United Kingdom
[5
]
Horizon Discovery, Waterbeach, Cambridge, United Kingdom
Author notes
Competing Interests: DG, AL, KH, MM, BD, SS, JCa, SB, GJ, JCl, PD, MP, SW, ME, EG, TF, VP and NR are current
or former employees, officers, consultants and/or share-holders of Inivata Ltd or
Inivata Inc. Inivata, InVision, TAm-Seq and eTAm-Seq are UK registered trademarks
of Inivata Ltd. DG, TF and NR are co-founders of Inivata Ltd. NR is a Board member
of Inivata. DG, SW, NR and TF are co-inventors or contributors on patent applications
that describe methods for the analysis of DNA fragments and applications of circulating
tumor DNA. AF-G, AW, JH, CF, GMJ and AD are current or former employees of LGC. HR-A
and KS are former employees of Horizon Discovery. This does not alter our adherence
to PLOS ONE policies on sharing data and materials, with restrictions described in
the Data Availability Statement.
Author information
Article
Publisher ID:
PONE-D-17-31337
DOI: 10.1371/journal.pone.0194630
PMC ID: 5856404
PubMed ID: 29547634
SO-VID: e154d343-8d9e-4ea5-91c0-ab66970b1ab9
Copyright © © 2018 Gale et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
History
Date
received
: 25
August
2017
Date
accepted
: 19
February
2018
Page count
Figures: 4,
Tables: 2,
Pages: 18
Funding
The analytical validation study was funded by Inivata. Inivata provided support in
the form of salaries for authors DG, AL, KH, MM, BD, SS, JCa, SB, GJ, JCl, PD, MP,
SW, ME, EG, TF, VP and NR, and participated in study design, data collection and analysis,
decision to publish, and preparation of the manuscript. The work on the novel full-process
control material performed by LGC was funded by the UK government Department for Business,
Energy & Industrial Strategy (BEIS) and Innovate UK under the project ‘Enabling stratified
medicine through cell and tissue reference standards for minimally invasive cancer
testing’ (Project Number: 101862) in partnership with Horizon Discovery. LGC provided
support in the form of salaries for authors AF-G, AW, JH, CF, GMJ and AD, and Horizon
Discovery provided support in the form of salaries for authors HR-A and KS. LGC and
Horizon Discovery did not have any additional role in the study design, data collection
and analysis, decision to publish, or preparation of the manuscript. The specific
roles of all authors are articulated in the ‘author contributions’ section.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Gene Identification and Analysis
Subject:
Mutation Detection
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Body Fluids
Subject:
Blood
Subject:
Blood Plasma
Subject:
Medicine and Health Sciences
Subject:
Surgical and Invasive Medical Procedures
Subject:
Biopsy
Subject:
Biology and life sciences
Subject:
Biochemistry
Subject:
Biomarkers
Subject:
Circulating tumor DNA
Subject:
Medicine and health sciences
Subject:
Diagnostic medicine
Subject:
Cancer detection and diagnosis
Subject:
Circulating tumor DNA
Subject:
Medicine and health sciences
Subject:
Oncology
Subject:
Cancer detection and diagnosis
Subject:
Circulating tumor DNA
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Mutagenesis and Gene Deletion Techniques
Subject:
Mutational Analysis
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Mutagenesis and Gene Deletion Techniques
Subject:
Mutational Analysis
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Mutation
Subject:
Biology and life sciences
Subject:
Molecular biology
Subject:
Molecular biology techniques
Subject:
Sequencing techniques
Subject:
DNA sequencing
Subject:
Next-Generation Sequencing
Subject:
Research and analysis methods
Subject:
Molecular biology techniques
Subject:
Sequencing techniques
Subject:
DNA sequencing
Subject:
Next-Generation Sequencing
Subject:
Biology and Life Sciences
Subject:
Computational Biology
Subject:
Genome Analysis
Subject:
Transcriptome Analysis
Subject:
Next-Generation Sequencing
Subject:
Biology and Life Sciences
Subject:
Genetics
Subject:
Genomics
Subject:
Genome Analysis
Subject:
Transcriptome Analysis
Subject:
Next-Generation Sequencing
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