About the possible origin and mechanism of circulating DNA apoptosis and active DNA release.

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

In addition to cell lysis, apoptosis has been advanced as the origin of circulating DNA on the basis of several observations. Plasma or serum DNA often presents a ladder pattern reminiscent of that displayed by apoptotic cells when subjected to electrophoresis. However, the phenomenon of active release of DNA from cells might also be expected to result in a ladder pattern on electrophoresis. Non-dividing cells, such as lymphocytes, frog auricles and cultured cell lines including HL-60, spontaneously release a nucleoprotein complex within a homeostatic system in which newly synthesized DNA is preferentially released.

Related collections

Author and article information

Journal

Journal ID (iso-abbrev): Clin Chim Acta

Title: Clinica chimica acta; international journal of clinical chemistry

Publisher: Elsevier BV

ISSN: 0009-8981

ISSN (Print): 0009-8981

Publication date (Electronic): Nov 2001

Volume: 313

Issue: 1-2

Affiliations

[1 ] Lab de Biochimie et Physiologie Vegetale, Faculté des Sciences, Pavillon des Isotopes, bvd d'Yvoy 20, 1211, Geneva, Switzerland.

Article

Publisher Item ID: S0009898101006659

DOI: 10.1016/s0009-8981(01)00665-9

PubMed ID: 11694251

SO-VID: 00913b54-a7b2-4e53-8742-b9c2a30bf165

History

Data availability:

Comments

Comment on this article

scite_

0

Smart Citations

0

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.