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Abstract
The study was designed to evaluate the hepatoprotective activity of aqueous extract
of central stem of Musa sapientum (AqMS) against carbon tetrachloride induced hepatotoxicity
in rats. Animals were divided into six groups. Group I served as normal control. Group
II, III, IV, V & VI were administered CCl(4) mixed with olive oil 1:1 (1.5 mL/kg)
I.P., twice a week for 5 weeks. Group II was maintained as CCl(4) intoxicated control.
Group III, IV and V received AqMS at a dose of 25, 50 and 100 mg/kg. Group VI received
silymarin 100 mg/kg for 5 weeks orally once daily. Marker enzymes of hepatic functions
estimated in serum were AST, ALT and ALP. Antioxidant parameters estimated were MDA
and GSH in blood and liver and SOD in blood, after fifth week, animals were sacrificed,
livers dissected out and evaluated for histomorphological changes.