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      International Journal of Nanomedicine (submit here)

      This international, peer-reviewed Open Access journal by Dove Medical Press focuses on the application of nanotechnology in diagnostics, therapeutics, and drug delivery systems throughout the biomedical field. Sign up for email alerts here.

      105,621 Monthly downloads/views I 7.033 Impact Factor I 10.9 CiteScore I 1.22 Source Normalized Impact per Paper (SNIP) I 1.032 Scimago Journal & Country Rank (SJR)

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      The Advances of Ceria Nanoparticles for Biomedical Applications in Orthopaedics

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          Abstract

          The ongoing biomedical nanotechnology has intrigued increasingly intense interests in cerium oxide nanoparticles, ceria nanoparticles or nano-ceria (CeO 2-NPs). Their remarkable vacancy-oxygen defect (VO) facilitates the redox process and catalytic activity. The verification has illustrated that CeO 2-NPs, a nanozyme based on inorganic nanoparticles, can achieve the anti-inflammatory effect, cancer resistance, and angiogenesis. Also, they can well complement other materials in tissue engineering (TE). Pertinent to the properties of CeO 2-NPs and the pragmatic biosynthesis methods, this review will emphasize the recent application of CeO 2-NPs to orthopedic biomedicine, in particular, the bone tissue engineering (BTE). The presentation, assessment, and outlook of the orthopedic potential and shortcomings of CeO 2-NPs in this review expect to provide reference values for the future research and development of therapeutic agents based on CeO 2-NPs.

          Most cited references137

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          Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applications

          Can Xu, Xiaogang Qu (2014)
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            Nanostructured ceria-based materials: synthesis, properties, and applications

            Hong Li, Liquan Chen, Chunwen Sun (2012)
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              Size dependency variation in lattice parameter and valency states in nanocrystalline cerium oxide

              Sameer K. Deshpande, Swanand Patil, Satyanarayana Kuchibhatla … (2005)
              Article 0 comments Cited 99 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Int J Nanomedicine
                Journal ID (iso-abbrev): Int J Nanomedicine
                Journal ID (publisher-id): ijn
                Journal ID (pmc): intjnano
                Title: International Journal of Nanomedicine
                Publisher: Dove
                ISSN (Print): 1176-9114
                ISSN (Electronic): 1178-2013
                Publication date (Electronic): 29 September 2020
                Publication date Collection: 2020
                Volume: 15
                Pages: 7199-7214
                Affiliations
                [1 ]Department of Orthopedic Surgery, The Second Hospital of Jilin University , Changchun 130041, People’s Republic of China
                Author notes
                Correspondence: Dankai Wu; Xiaoyu Yang Department of Orthopedic Surgery, The Second Hospital of Jilin University , Changchun, TX130041, People’s Republic of China Email wudankai@163.com; yangxiaoy@jlu.edu.cn
                Author information
                http://orcid.org/0000-0001-9078-5187
                http://orcid.org/0000-0002-2015-9989
                Article
                Publisher ID: 270229
                DOI: 10.2147/IJN.S270229
                PMC ID: 7535115
                PubMed ID: 33061376
                SO-VID: de67cac1-3dcf-4a37-a432-f31ff429edfd
                Copyright © © 2020 Li et al.
                License:

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                Date received : 01 July 2020
                Date accepted : 10 August 2020
                Page count
                Figures: 4, Tables: 3, References: 142, Pages: 16
                Categories
                Subject: Review

                ScienceOpen disciplines: Molecular medicine
                Keywords: ceo2-nps,green synthesis,ros,bone tissue engineering,coating,orthopedic implants
                Data availability:
                ScienceOpen disciplines: Molecular medicine
                Keywords: ceo2-nps, green synthesis, ros, bone tissue engineering, coating, orthopedic implants

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