For Publishers
DiscoveryMetadataPeer reviewHostingPublishing
For Researchers
JoinPublishReviewCollect
Register
Blog
About
Search
Advanced search
My ScienceOpen
Search
For Publishers
For Researchers
Blog
About
5
views
192
references
 Top references
cited by
11
    
0 reviews
 Review
0
comments
 Comment
0
recommends
+1 Recommend
0 collections
    0
    shares
      466
      similar
       All similar
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Advances in Functionalized Photosensitive Polymeric Nanocarriers

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The synthesis of light-responsive nanocarriers (LRNs) with a variety of surface functional groups and/or ligands has been intensively explored for space-temporal controlled cargo release. LRNs have been designed on demand for photodynamic-, photothermal-, chemo-, and radiotherapy, protected delivery of bioactive molecules, such as smart drug delivery systems and for theranostic duties. LRNs trigger the release of cargo by a light stimulus. The idea of modifying LRNs with different moieties and ligands search for site-specific cargo delivery imparting stealth effects and/or eliciting specific cellular interactions to improve the nanosystems’ safety and efficacy. This work reviews photoresponsive polymeric nanocarriers and photo-stimulation mechanisms, surface chemistry to link ligands and characterization of the resultant nanosystems. It summarizes the interesting biomedical applications of functionalized photo-controlled nanocarriers, highlighting the current challenges and opportunities of such high-performance photo-triggered delivery systems.

          Related collections

          Most cited references192

          • Record: found
          • Abstract: found
          • Article: not found

          A DNA-based method for rationally assembling nanoparticles into macroscopic materials.

          C Mirkin, R Letsinger, R Mucic … (1996)
          Colloidal particles of metals and semiconductors have potentially useful optical, optoelectronic and material properties that derive from their small (nanoscopic) size. These properties might lead to applications including chemical sensors, spectroscopic enhancers, quantum dot and nanostructure fabrication, and microimaging methods. A great deal of control can now be exercised over the chemical composition, size and polydispersity of colloidal particles, and many methods have been developed for assembling them into useful aggregates and materials. Here we describe a method for assembling colloidal gold nanoparticles rationally and reversibly into macroscopic aggregates. The method involves attaching to the surfaces of two batches of 13-nm gold particles non-complementary DNA oligonucleotides capped with thiol groups, which bind to gold. When we add to the solution an oligonucleotide duplex with 'sticky ends' that are complementary to the two grafted sequences, the nanoparticles self-assemble into aggregates. This assembly process can be reversed by thermal denaturation. This strategy should now make it possible to tailor the optical, electronic and structural properties of the colloidal aggregates by using the specificity of DNA interactions to direct the interactions between particles of different size and composition.
          Article 0 comments Cited 986 times – based on 0 reviews     Review now
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Biodegradable polymeric nanoparticles based drug delivery systems.

            Avnesh Kumari, Sudesh Yadav, Subhash C Yadav (2010)
            Biodegradable nanoparticles have been used frequently as drug delivery vehicles due to its grand bioavailability, better encapsulation, control release and less toxic properties. Various nanoparticulate systems, general synthesis and encapsulation process, control release and improvement of therapeutic value of nanoencapsulated drugs are covered in this review. We have highlighted the impact of nanoencapsulation of various disease related drugs on biodegradable nanoparticles such as PLGA, PLA, chitosan, gelatin, polycaprolactone and poly-alkyl-cyanoacrylates.
            Article 0 comments Cited 410 times – based on 0 reviews     Review now
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Engineered nanoparticles for drug delivery in cancer therapy.

              Tianmeng Sun, Yu Zhang, Bo Pang … (2014)
              In medicine, nanotechnology has sparked a rapidly growing interest as it promises to solve a number of issues associated with conventional therapeutic agents, including their poor water solubility (at least, for most anticancer drugs), lack of targeting capability, nonspecific distribution, systemic toxicity, and low therapeutic index. Over the past several decades, remarkable progress has been made in the development and application of engineered nanoparticles to treat cancer more effectively. For example, therapeutic agents have been integrated with nanoparticles engineered with optimal sizes, shapes, and surface properties to increase their solubility, prolong their circulation half-life, improve their biodistribution, and reduce their immunogenicity. Nanoparticles and their payloads have also been favorably delivered into tumors by taking advantage of the pathophysiological conditions, such as the enhanced permeability and retention effect, and the spatial variations in the pH value. Additionally, targeting ligands (e.g., small organic molecules, peptides, antibodies, and nucleic acids) have been added to the surface of nanoparticles to specifically target cancerous cells through selective binding to the receptors overexpressed on their surface. Furthermore, it has been demonstrated that multiple types of therapeutic drugs and/or diagnostic agents (e.g., contrast agents) could be delivered through the same carrier to enable combination therapy with a potential to overcome multidrug resistance, and real-time readout on the treatment efficacy. It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.
              Article 0 comments Cited 390 times – based on 0 reviews     Review now
                Bookmark
                All references

                Author and article information

                Contributors
                Cristina Neves: Role: Academic Editor
                Journal
                Journal ID (nlm-ta): Polymers (Basel)
                Journal ID (iso-abbrev): Polymers (Basel)
                Journal ID (publisher-id): polymers
                Title: Polymers
                Publisher: MDPI
                ISSN (Electronic): 2073-4360
                Publication date (Electronic): 27 July 2021
                Publication date Collection: August 2021
                Volume: 13
                Issue: 15
                Electronic Location Identifier: 2464
                Affiliations
                Max Planck Tandem Group in Nanobioengineering, University of Antioquia, Complejo Ruta N, Calle 67 N° 52-20, Medellín 050010, Colombia; maritza.fernandez@ 123456udea.edu.co
                Author notes
                Author information
                https://orcid.org/0000-0001-6249-8092
                Article
                Publisher ID: polymers-13-02464
                DOI: 10.3390/polym13152464
                PMC ID: 8348146
                PubMed ID: 34372067
                SO-VID: dc1e454c-f908-4a3f-9713-0f8f6f0bbc90
                Copyright © © 2021 by the authors.
                License:

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( https://creativecommons.org/licenses/by/4.0/).

                History
                Date received : 15 June 2021
                Date accepted : 01 July 2021
                Categories
                Subject: Review

                Keywords: functional nanoparticle,photoresponsive nanoparticle,light-responsive drug delivery,polymer nanocarrier
                Data availability:
                Keywords: functional nanoparticle, photoresponsive nanoparticle, light-responsive drug delivery, polymer nanocarrier

                Comments

                Comment on this article

                scite_

                Similar content466

                See all similar

                Cited by11

                See all cited by

                Most referenced authors3,702

                See all reference authors