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Abstract
Laboratory trials made with five inactivated (O78 K80) Escherichia coli vaccines showed
that the greatest degree of protection against an intramuscular challenge with the
homologous strain was obtained with an alum precipitated vaccine. This vaccine was
equally effective when administered by the subcutaneous, intramuscular or intraperitoneal
route. Maximal protection, persisting for at least six weeks, was obtained by inoculating
chicks at three weeks of age with a dose of approximately 1-5 X 10(9) cells in 0.5
ml. Some degree of protection was obtained, however, in chicks vaccinated earlier.
There was no evidence that this vaccine provided any cross protection against other
pathogenic serotypes of E coli. No adverse effect was noted on growth rate or carcase
quality in the chicks vaccinated. Immunological studies showed that protection was
not related to the production of O and K serum agglutinins.