Heteroaromatization with 4-Hydroxycoumarin Part II: Synthesis of Some New Pyrano[2,3-d]pyrimidines, [1,2,4]triazolo[1,5-c]pyrimidines and Pyrimido[1,6-b]-[1,2,4]triazine Derivatives.

El-Agrody, A.M.; Abd El-Latif, M.S.; El-Hady, N.A.; Fakery, A.H.; Bedair, A.H.

doi:10.3390/60600519

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Heteroaromatization with 4-Hydroxycoumarin Part II: Synthesis of Some New Pyrano[2,3-d]pyrimidines, [1,2,4]triazolo[1,5-c]pyrimidines and Pyrimido[1,6-b]-[1,2,4]triazine Derivatives.

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Author(s): A.M. El-Agrody ¹ ^, ^* , M.S. Abd El-Latif ¹ , N.A. El-Hady ² , A.H. Fakery ¹ , A.H. Bedair ¹

Publication date (Electronic): 31 May 2001

Journal: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

Publisher: MDPI

Keywords: Pyrano[3,2-c][1]benzopyrans, Pyrano[2,3-d]pyrimidines, [1,2,4]-triazolo-[1,5-c]pyrimidines, Pyrimido[1,6-b][1,2,4]triazine, antimicrobial activities

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Abstract

A variety of novel [1,2,4]triazolo[1,5-c]pyrimidine-13-ones ( 4a- f) and ( 5b- d) could be obtained via reaction of 9-amino-7-(4’-chlorophenyl)-8,9-dihydro-8-imino-6 H,7H-[1]benzopyrano[3`,4`:5,6]pyrano[2,3-d]pyrimidine-6-one ( 3) with a variety of reagents. Pyrano[2,3-d]pyrimidine-6-ones 5a, 8a-c and pyrimido[1,6-b][1,2,4]-triazine-3,14-dione ( 6) were also prepared. The antimicrobial activity of some of the synthesized compounds was tested.