Organoids as an in vitro model of human development and disease.

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Abstract

The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical applications. This near-physiological 3D model facilitates an accurate study of a range of in vivo biological processes including tissue renewal, stem cell/niche functions and tissue responses to drugs, mutation or damage. In this Review, we discuss the current achievements, challenges and potential applications of this technique.

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Journal

Journal ID (iso-abbrev): Nat. Cell Biol.

Title: Nature cell biology

ISSN (Electronic): 1476-4679

ISSN (Print): 1465-7392

Publication date (Electronic): Mar 2016

Volume: 18

Issue: 3

Affiliations

[1 ] A*STAR Institute of Medical Biology, 8A Biomedical Grove, 06-06 Immunos, 138648, Singapore.

[2 ] Centre for Regenerative Medicine, 47 Little France Crescent, University of Edinburgh, Edinburgh, EH16 4TJ, UK.

[3 ] Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 117596, Singapore.

Article

Publisher Item ID: ncb3312

DOI: 10.1038/ncb3312

PubMed ID: 26911908

SO-VID: d758d73e-9b00-4d14-a535-c7fc0fa617c1

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