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      Distinguishing Zika and Dengue Viruses through Simple Clinical Assessment, Singapore

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          Abstract

          Dengue virus and Zika virus coexist in tropical regions in Asia where healthcare resources are limited; differentiating the 2 viruses is challenging. We showed in a case–control discovery cohort, and replicated in a validation cohort, that the diagnostic indices of conjunctivitis, platelet count, and monocyte count reliably distinguished between these viruses.

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          Dengue Prevention and 35 Years of Vector Control in Singapore

          Eng-Eong Ooi, Kee-Tai Goh, Duane J. Gubler (2006)
          Article 0 comments Cited 79 times – based on 0 reviews     Review now
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            Diagnostic Accuracy of Parameters for Zika and Dengue Virus Infections, Singapore

            Hanley J Ho, Joshua G.X. Wong, Win Mar Kyaw … (2017)
            Singapore experienced its first documented Zika virus outbreak in 2016. We identified clinical and laboratory parameters that increase the probability for Zika or dengue virus infection. Early during the illness, combinations of key parameters obtained through clinical assessment and hematologic tests can help distinguish between these infections.
            Article 0 comments Cited 6 times – based on 0 reviews     Review now
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              The inevitable colonisation of Singapore by Zika virus

              Dale Fisher, Jeffery Cutter (2016)
              Singapore is endemic for Dengue virus, with approximately 10,000 to 20,000 annual cases reported in recent years. In 2012, Chikungunya was introduced, although the numbers of cases reported is much fewer. The current Zika virus pandemic originating in Brazil represents a threat to all regions with Aedes mosquitoes, particularly those well connected by travellers. In this respect, it was felt inevitable that Singapore would eventually realise its third endemic flavivirus. In late August 2016, a primary care practitioner observed a cluster of geographically linked patients attending with fever and rash. This resulted in the first identification of locally transmitted Zika in Singapore on August 27, 2016. This prompted a robust response in an attempt to stop further spread, which continued for approximately 10 days until a large number of laboratory-confirmed cases were found as a result of active case finding. Surprisingly, the strain was later identified to be of Asian lineage and distinct from that originating in the Americas, prompting speculation over the epidemiology of this under recognised virus in Asia.
              Article 0 comments Cited 5 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Emerg Infect Dis
                Journal ID (iso-abbrev): Emerging Infect. Dis
                Journal ID (publisher-id): EID
                Title: Emerging Infectious Diseases
                Publisher: Centers for Disease Control and Prevention
                ISSN (Print): 1080-6040
                ISSN (Electronic): 1080-6059
                Publication date (Print): August 2018
                Volume: 24
                Issue: 8
                Pages: 1565-1568
                Affiliations
                [1]National University Health System, Singapore (G. Yan, L. Pang, A.R. Cook, M.S. Win, S.S. Ho, P.A. Tambyah, D. Fisher, J. Oon, N. Bagdasarian, N. Smitasin, L.Y.A. Chai);
                [2]National University of Singapore (L. Pang, A.R. Cook, P.A. Tambyah, D. Fisher, N. Bagdasarian, L.Y.A. Chai);
                [3]Tan Tock Seng Hospital, Singapore (H.J. Ho, J.G.X. Wong, D.C. Lye, Y.S. Leo, A. Chow);
                [4]National University Cancer Institute, Singapore (M.S. Win, L.Y.A. Chai);
                [5]National Healthcare Group, Singapore (A.L. Khoo);
                [6]National University Hospital, Singapore (C.K. Lee, B. Yan, R. Jureen)
                Author notes
                Address for correspondence: Louis Yi Ann Chai, National University Health System—Division of Infectious Diseases, University Medicine Cluster, NUHS Tower Block, 1E Kent Ridge Rd, Singapore 119228, Singapore; email: chailouis@ 123456hotmail.com
                Article
                Publisher ID: 17-1883
                DOI: 10.3201/eid2408.171883
                PMC ID: 6056111
                PubMed ID: 30016242
                SO-VID: d71ada2c-ff36-4b73-a13f-d58bca780dc1
                History
                Categories
                Subject: Dispatch
                Subject: Dispatch
                Subject: Distinguishing Zika and Dengue Viruses through Simple Clinical Assessment, Singapore

                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: southeast asia,dengue virus,zika virus,conjunctivitis,platelets,viruses,zoonoses,singapore
                Data availability:
                ScienceOpen disciplines: Infectious disease & Microbiology
                Keywords: southeast asia, dengue virus, zika virus, conjunctivitis, platelets, viruses, zoonoses, singapore

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