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      Pore Strategy Design of a Novel NiTi-Nb Biomedical Porous Scaffold Based on a Triply Periodic Minimal Surface

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          Abstract

          The pore strategy is one of the important factors affecting the biomedical porous scaffold at the same porosity. In this work, porous scaffolds were designed based on the triply periodic minimal surface (TPMS) structure under the same porosity and different pore strategies (pore size and size continuous gradient distribution) and were successfully prepared using a novel Ni 46.5Ti 44.5Nb 9 alloy and selective laser melting (SLM) technology. After that, the effects of the pore strategies on the microstructure, mechanical properties, and permeability of porous scaffolds were systematically investigated. The results showed that the Ni 46.5Ti 44.5Nb 9 scaffolds have a low elastic modulus (0.80–1.05 GPa) and a high ductility (15.3–19.1%) compared with previous works. The pore size has little effect on their mechanical properties, but increasing the pore size significantly improves the permeability due to the decrease in specific surfaces. The continuous gradient distribution of the pore size changes the material distribution of the scaffold, and the smaller porosity structure has a better load-bearing capacity and contributes primarily to the high compression strength. The local high porosity structure bears more fluid flow, which can improve the permeability of the overall scaffold. This work can provide theoretical guidance for the design of porous scaffolds.

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          Ti based biomaterials, the ultimate choice for orthopaedic implants – A review

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            Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: A review.

            One of the critical issues in orthopaedic regenerative medicine is the design of bone scaffolds and implants that replicate the biomechanical properties of the host bones. Porous metals have found themselves to be suitable candidates for repairing or replacing the damaged bones since their stiffness and porosity can be adjusted on demands. Another advantage of porous metals lies in their open space for the in-growth of bone tissue, hence accelerating the osseointegration process. The fabrication of porous metals has been extensively explored over decades, however only limited controls over the internal architecture can be achieved by the conventional processes. Recent advances in additive manufacturing have provided unprecedented opportunities for producing complex structures to meet the increasing demands for implants with customized mechanical performance. At the same time, topology optimization techniques have been developed to enable the internal architecture of porous metals to be designed to achieve specified mechanical properties at will. Thus implants designed via the topology optimization approach and produced by additive manufacturing are of great interest. This paper reviews the state-of-the-art of topological design and manufacturing processes of various types of porous metals, in particular for titanium alloys, biodegradable metals and shape memory alloys. This review also identifies the limitations of current techniques and addresses the directions for future investigations.
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              Additive manufacturing: scientific and technological challenges, market uptake and opportunities

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                Author and article information

                Contributors
                Journal
                Front Bioeng Biotechnol
                Front Bioeng Biotechnol
                Front. Bioeng. Biotechnol.
                Frontiers in Bioengineering and Biotechnology
                Frontiers Media S.A.
                2296-4185
                08 June 2022
                2022
                : 10
                : 910475
                Affiliations
                [1] 1 College of Mechanical and Electronic Engineering , Shandong University of Science and Technology , Qingdao, China
                [2] 2 State Key Laboratory of Metal Matrix Composites , Shanghai Jiao Tong University , Shanghai, China
                [3] 3 Affiliated Hospital of Youjiang Medical University for Nationalities , Baise, China
                [4] 4 3D Printing Clinical Translational and Regenerative Medicine Center , Shenzhen Shekou People’s Hospital , Shenzhen, China
                Author notes

                Edited by: Roman Surmenev, Tomsk Polytechnic University, Russia

                Reviewed by: Xu Song, The Chinese University of Hong Kong, China

                Qiang Wang, China Medical University, China

                This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology

                Article
                910475
                10.3389/fbioe.2022.910475
                9214207
                35757802
                d6b743e5-4589-4682-8763-3e15ca265eaa
                Copyright © 2022 Lv, Liu, Wang, Tang, Lin, Liu, Wei and Wang.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 01 April 2022
                : 06 May 2022
                Categories
                Bioengineering and Biotechnology
                Original Research

                additive manufacturing,triply periodic minimal surfaces,niti-nb,porous scaffolds,pore strategy

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