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      Person‐centred, integrated non‐communicable disease and HIV decentralized drug distribution in Eswatini and South Africa: outcomes and challenges

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          Abstract

          Introduction

          Non‐communicable diseases (NCDs) are highly prevalent in people living with HIV above 50 years of age and account for increasing mortality. There is little published evidence supporting person‐centred, integrated models of HIV care, hypertension and diabetes treatment in southern Africa, and no data demonstrating mortality reduction. Where clinical visits for NCDs and HIV cannot be combined, integrated medication delivery presents an opportunity to streamline care and reduce patient costs. We present experiences of integrated HIV and NCD medication delivery in Eswatini and South Africa, focusing on programme successes and implementation challenges. Programmatic data from Eswatini's Community Health Commodities Distribution (CHCD) from April 2020 to December 2021 and South Africa's Central Chronic Medicines Dispensing and Distribution (CCMDD) from January 2016 to December 2021 were provided by programme managers and are summarized here.

          Discussion

          Launched in 2020, Eswatini's CHCD provides over 28,000 people with and without HIV with integrated services, including HIV testing, CD4 cell count testing, antiretroviral therapy refills, viral load monitoring and pre‐exposure prophylaxis alongside NCD services, including blood pressure and glucose monitoring and hypertension and diabetes medication refills.  Communities designate neighbourhood care points and central gathering places for person‐centred medication dispensing.  This programme reported fewer missed medication refill appointments among clients in community settings compared to facility‐based settings. South Africa's CCMDD utilizes decentralized drug distribution to provide medications for over 2.9 million people, including those living with HIV, hypertension and diabetes.  CCMDD incorporates community‐based pickup points, facility “fast lanes” and adherence clubs with public sector health facilities and private sector medication collection units.  There are no out‐of‐pocket payments for medications or testing commodities.  Wait‐times for medication refills are lower at CCMDD sites than facility‐based sites.  Innovations to reduce stigma include uniformly labelled medication packages for NCD and HIV medications.

          Conclusions

          Eswatini and South Africa demonstrate person‐centred models for HIV and NCD integration through decentralized drug distribution. This approach adapts medication delivery to serve individual needs and decongest centralized health facilities while efficiently delivering NCD care.  To bolster programme uptake, additional reporting of integrated decentralized drug distribution models should include HIV and NCD outcomes and mortality trends.

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          Most cited references17

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          Burden of non-communicable diseases in sub-Saharan Africa, 1990–2017: results from the Global Burden of Disease Study 2017

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            Noncommunicable diseases among HIV-infected persons in low-income and middle-income countries: a systematic review and meta-analysis

            Objective: To appropriately identify and treat noncommunicable diseases (NCDs) among persons living with HIV (PLHIV) in low-and-middle-income countries (LMICs), it is imperative to understand the burden of NCDs among PLHIV in LMICs and the current management of the diseases. Design: Systematic review and meta-analysis. Methods: We examined peer-reviewed literature published between 1 January 2010 and 31 December 2016 to assess currently available evidence regarding HIV and four selected NCDs (cardiovascular disease, cervical cancer, depression, and diabetes) in LMICs with a focus on sub-Saharan Africa. The databases, PubMed/MEDLINE, Cochrane Review, and Scopus, were searched to identify relevant literature. For conditions with adequate data available, pooled estimates for prevalence were generated using random fixed effects models. Results: Six thousand one hundred and forty-three abstracts were reviewed, 377 had potentially relevant prevalence data and 141 were included in the summary; 57 were selected for quantitative analysis. Pooled estimates for NCD prevalence were hyper-tension 21.2% (95% CI 16.3–27.1), hypercholesterolemia 22.2% (95% CI 14.7–32.1), elevated low-density lipoprotein 23.2% (95% CI 15.2–33.6), hypertriglyceridemia 27.2% (95% CI 20.7–34.8), low high-density lipoprotein 52.3% (95% CI 35.6–62.8), obesity 7.8% (95% CI 4.3–13.9), and depression 24.4% (95% CI 12.5–42.1). Invasive cervical cancer and diabetes prevalence were 1.3–1.7 and 1.3–18%, respectively. Few NCD-HIV integrated programs with screening and management approaches that are contextually appropriate for resource-limited settings exist. Conclusion: Improved data collection and surveillance of NCDs among PLHIV in LMICs are necessary to inform integrated HIV/NCD care models. Although efforts to integrate care exist, further research is needed to optimize the efficacy of these programs.
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              Models of integration of HIV and noncommunicable disease care in sub-Saharan Africa: lessons learned and evidence gaps.

              To describe available models of HIV and noncommunicable disease (NCD) care integration in sub-Saharan Africa (SSA).
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                Author and article information

                Contributors
                degoldstein@usaid.gov
                Journal
                J Int AIDS Soc
                J Int AIDS Soc
                10.1002/(ISSN)1758-2652
                JIA2
                Journal of the International AIDS Society
                John Wiley and Sons Inc. (Hoboken )
                1758-2652
                06 July 2023
                July 2023
                : 26
                : Suppl 1 ( doiID: 10.1002/jia2.v26.S1 )
                : e26113
                Affiliations
                [ 1 ] Office of HIV/AIDS USAID Washington DC USA
                [ 2 ] Global HIV Hepatitis and Sexually Transmitted Infections Programmes World Health Organization Geneva Switzerland
                [ 3 ] Eswatini National AIDS Program Mbabane Eswatini
                [ 4 ] ICAP Columbia University Mbabane Eswatini
                [ 5 ] National Department of Health Pretoria South Africa
                [ 6 ] FHI 360 Durham North Carolina USA
                [ 7 ] Resolve to Save Lives Abuja Nigeria
                [ 8 ] ICAP Columbia University Mailman School of Public Health New York New York USA
                Author notes
                [*] [* ] Corresponding author: Deborah Goldstein, Office of HIV/AIDS, USAID, 500 D St SW, Washington, DC 20547, USA. ( degoldstein@ 123456usaid.gov )

                Author information
                https://orcid.org/0000-0003-1858-3905
                https://orcid.org/0000-0001-9442-7854
                Article
                JIA226113
                10.1002/jia2.26113
                10323318
                37408477
                d69f55ae-26d2-4427-840a-cf800af1bb29
                © 2023 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

                History
                : 28 November 2022
                : 09 May 2023
                Page count
                Figures: 0, Tables: 1, Pages: 6, Words: 4107
                Categories
                Commentary
                Commentary
                Custom metadata
                2.0
                July 2023
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.3.0 mode:remove_FC converted:06.07.2023

                Infectious disease & Microbiology
                non‐communicable disease,integration,person‐centred care,decentralized drug distribution,hiv,hypertension,diabetes

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