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Influenza A(H1N1)pdm09 virus exhibiting enhanced cross-resistance to oseltamivir and peramivir due to a dual H275Y/G147R substitution, Japan, March 2016.
Emi Takashita
1 ,
Seiichiro Fujisaki ,
Masayuki Shirakura ,
Kazuya Nakamura ,
Noriko Kishida ,
Tomoko Kuwahara ,
Yukie Shimazu ,
Takeshi Shimomura ,
Shinji Watanabe ,
Takato Odagiri
Jun 16 2016
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Abstract
An influenza A(H1N1)pdm09 virus carrying a G147R substitution in combination with an H275Y substitution in the neuraminidase protein, which confers cross-resistance to oseltamivir and peramivir, was detected from an immunocompromised inpatient in Japan, March 2016. This dual H275Y/G147R mutant virus exhibited enhanced cross-resistance to both drugs compared with the single H275Y mutant virus and reduced susceptibility to zanamivir, although it showed normal inhibition by laninamivir.