Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II)

Author(s): Jiangjiexing Wu ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Xiaoyu Wang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Quan Wang ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Zhangping Lou ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Sirong Li ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Yunyao Zhu ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Li Qin ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵ , Hui Wei ¹ ^, ² ^, ³ ^, ⁴ ^, ⁵

Publication date (Electronic): 2019

Journal: Chemical Society Reviews

Publisher: Royal Society of Chemistry (RSC)

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Abstract

An updated comprehensive review to help researchers understand nanozymes better and in turn to advance the field.

Abstract

Nanozymes are nanomaterials with enzyme-like characteristics ( Chem. Soc. Rev., 2013, 42, 6060–6093). They have been developed to address the limitations of natural enzymes and conventional artificial enzymes. Along with the significant advances in nanotechnology, biotechnology, catalysis science, and computational design, great progress has been achieved in the field of nanozymes since the publication of the above-mentioned comprehensive review in 2013. To highlight these achievements, this review first discusses the types of nanozymes and their representative nanomaterials, together with the corresponding catalytic mechanisms whenever available. Then, it summarizes various strategies for modulating the activity and selectivity of nanozymes. After that, the broad applications from biomedical analysis and imaging to theranostics and environmental protection are covered. Finally, the current challenges faced by nanozymes are outlined and the future directions for advancing nanozyme research are suggested. The current review can help researchers know well the current status of nanozymes and may catalyze breakthroughs in this field.

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Zirconium-Metalloporphyrin PCN-222: Mesoporous Metal-Organic Frameworks with Ultrahigh Stability as Biomimetic Catalysts

Hai-Long Jiang, Zhangwen Wei, Dawei Feng … (2013)

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Is Open Access

Tumor-selective catalytic nanomedicine by nanocatalyst delivery

Minfeng Huo, Liying Wang, Yu Chen … (2017)

Tumor cells metabolize in distinct pathways compared with most normal tissue cells. The resulting tumor microenvironment would provide characteristic physiochemical conditions for selective tumor modalities. Here we introduce a concept of sequential catalytic nanomedicine for efficient tumor therapy by designing and delivering biocompatible nanocatalysts into tumor sites. Natural glucose oxidase (GOD, enzyme catalyst) and ultrasmall Fe3O4 nanoparticles (inorganic nanozyme, Fenton reaction catalyst) have been integrated into the large pore-sized and biodegradable dendritic silica nanoparticles to fabricate the sequential nanocatalyst. GOD in sequential nanocatalyst could effectively deplete glucose in tumor cells, and meanwhile produce a considerable amount of H2O2 for subsequent Fenton-like reaction catalyzed by Fe3O4 nanoparticles in response to mild acidic tumor microenvironment. Highly toxic hydroxyl radicals are generated through these sequential catalytic reactions to trigger the apoptosis and death of tumor cells. The current work manifests a proof of concept of catalytic nanomedicine by approaching selectivity and efficiency concurrently for tumor therapeutics.