INTEGRATIVE LITERATURE REVIEW :  PREVENTION OF NEUROLOGICAL COMPLICATIONS OF HERPES ZOSTER IN ADULTS - ADVANCES, CHALLENGES AND PERSPECTIVES

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Abstract

Herpes zoster is a viral disease that can cause neurological complications in adults. In this integrative literature review, 15 scientific articles published in the last five years were analyzed to explore the main topics related to neurological complications of herpes zoster in adults. The topics covered include epidemiology, vaccination, risk factors, treatment, impact on quality of life, and multidisciplinary approach. Herpes zoster has an increased incidence in the elderly and immunocompromised individuals, and is associated with a higher risk of stroke. Vaccination is an effective strategy for preventing the disease and its complications, such as postherpetic neuralgia. Risk factors such as advanced age and severe pain during the acute episode are associated with the development of postherpetic neuralgia. Corticosteroids are an effective treatment option for reducing the risk of this complication. Herpes zoster and postherpetic neuralgia can have a significant impact on patients’ quality of life, especially in the physical and emotional aspects. A multidisciplinary approach involving healthcare professionals from different fields is essential for comprehensive and effective care.

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Most cited references 18

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Systematic review of incidence and complications of herpes zoster: towards a global perspective

Kosuke Kawai, Berhanu G Gebremeskel, Camilo J Acosta (2014)

Objective The objective of this study was to characterise the incidence rates of herpes zoster (HZ), also known as shingles, and risk of complications across the world. Design We systematically reviewed studies examining the incidence rates of HZ, temporal trends of HZ, the risk of complications including postherpetic neuralgia (PHN) and HZ-associated hospitalisation and mortality rates in the general population. The literature search was conducted using PubMed, EMBASE and the WHO library up to December 2013. Results We included 130 studies conducted in 26 countries. The incidence rate of HZ ranged between 3 and 5/1000 person-years in North America, Europe and Asia-Pacific, based on studies using prospective surveillance, electronic medical record data or administrative data with medical record review. A temporal increase in the incidence of HZ was reported in the past several decades across seven countries, often occurring before the introduction of varicella vaccination programmes. The risk of developing PHN varied from 5% to more than 30%, depending on the type of study design, age distribution of study populations and definition. More than 30% of patients with PHN experienced persistent pain for more than 1 year. The risk of recurrence of HZ ranged from 1% to 6%, with long-term follow-up studies showing higher risk (5–6%). Hospitalisation rates ranged from 2 to 25/100 000 person-years, with higher rates among elderly populations. Conclusions HZ is a significant global health burden that is expected to increase as the population ages. Future research with rigorous methods is important.

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Clinical practice: Herpes zoster.

Jeffrey I Cohen (2013)

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The impact of herpes zoster and postherpetic neuralgia on health-related quality of life: a prospective study.

Myron Levin, Kenneth Schmader, David Patrick … (2010)

Vaccination against herpes zoster is being considered in many countries. We conducted a multicentre prospective study to describe the impact of herpes zoster and postherpetic neuralgia on health-related quality of life. From October 2005 to July 2006, 261 outpatients aged 50 years or older with herpes zoster were recruited from the clinical practices of 83 physicians within 14 days after rash onset. The Zoster Brief Pain Inventory was used to measure severity of pain and interference with activities of daily living because of pain. The EuroQol EQ-5D assessment tool was used to measure quality of life. These outcomes were assessed at recruitment and on days 7, 14, 21, 30, 60, 90, 120, 150 and 180 following recruitment. Acute herpes zoster interfered in all health domains, especially sleep (64% of participants), enjoyment of life (58%) and general activities (53%). The median duration of pain was 32.5 days. The median duration of interference with activities of daily living because of pain varied between 27 and 30 days. Overall, 24% of the participants had postherpetic neuralgia (pain for more than 90 days after rash onset). Anxiety and depression, enjoyment of life, mood and sleep were most frequently affected during the postherpetic neuralgia period. The mean EQ-5D score was 0.59 at enrolment and remained at 0.67 at all follow-up points among participants who reported clinically significant pain. These data support the need for preventive strategies and additional early intervention to reduce the burden of herpes zoster and postherpetic neuralgia.

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Author and article information

Journal

Title: Health and Society

Abbreviated Title: hs

Publisher: Periodicojs

ISSN (Electronic): 2763-5724

Publication date Created: July 11 2023

Publication date (Electronic): July 11 2023

Volume: 3

Issue: 04

Pages: 16-30

Article

DOI: 10.51249/hs.v3i04.1447

SO-VID: d5d27f74-bbab-404f-844b-1be9e9fbee6a

License:

https://creativecommons.org/licenses/by/4.0

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