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      Biological Activities of Phenolic Compounds of Extra Virgin Olive Oil

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          Abstract

          Over the last few decades, multiple biological properties, providing antioxidant, anti-inflammatory, chemopreventive and anti-cancer benefits, as well as the characteristic pungent and bitter taste, have been attributed to Extra Virgin Olive Oil (EVOO) phenols. In particular, growing efforts have been devoted to the study of the antioxidants of EVOO, due to their importance from health, biological and sensory points of view. Hydrophilic and lipophilic phenols represent the main antioxidants of EVOO, and they include a large variety of compounds. Among them, the most concentrated phenols are lignans and secoiridoids, with the latter found exclusively in the Oleaceae family, of which the drupe is the only edible fruit. In recent years, therefore, we have tackled the study of the main properties of phenols, including the relationships between their biological activity and the related chemical structure. This review, in fact, focuses on the phenolic compounds of EVOO, and, in particular, on their biological properties, sensory aspects and antioxidant capacity, with a particular emphasis on the extension of the product shelf-life.

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          Most cited references107

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          Phytochemistry: ibuprofen-like activity in extra-virgin olive oil.

          Newly pressed extra-virgin olive oil contains oleocanthal--a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.
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            Atherosclerosis: Basic Mechanisms

            Circulation, 91(9), 2488-2496
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              Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil.

              The Mediterranean diet is associated with a lower incidence of chronic degenerative diseases and higher life expectancy. These health benefits have been partially attributed to the dietary consumption of extra virgin olive oil (EVOO) by Mediterranean populations, and more specifically the phenolic compounds naturally present in EVOO. Studies involving humans and animals (in vivo and in vitro) have demonstrated that olive oil phenolic compounds have potentially beneficial biological effects resulting from their antimicrobial, antioxidant and anti-inflammatory activities. This paper summarizes current knowledge on the biological activities of specific olive oil phenolic compounds together with information on their concentration in EVOO, bioavailability and stability over time. Copyright © 2011 Elsevier Ltd. All rights reserved.
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                Author and article information

                Journal
                Antioxidants (Basel)
                Antioxidants (Basel)
                antioxidants
                Antioxidants
                MDPI
                2076-3921
                20 December 2013
                March 2014
                : 3
                : 1
                : 1-23
                Affiliations
                Dipartimento di Scienze Economico-Estimative e degli Alimenti, Sezione di Tecnologie e Biotecnologie degli Alimenti, Università degli Studi di Perugia, Via S. Costanzo, Perugia 06126, Italy; E-Mails: b.sordini@ 123456gmail.com (B.S.); sonia.esposto@ 123456unipg.it (S.E.); stefania.urbani@ 123456libero.it (S.U.); gianluca.veneziani@ 123456progetti.unipg.it (G.V.); ilonadimaio@ 123456libero.it (I.M.); roberto.selvaggini@ 123456unipg.it (R.S.); agnese.taticchi@ 123456unipg.it (A.T.)
                Author notes
                [* ]Author to whom correspondence should be addressed; E-Mail: maurizio.servili@ 123456unipg.it ; Tel.: +39-075-585-7942; Fax: +39-075-585-7916.
                Article
                antioxidants-03-00001
                10.3390/antiox3010001
                4665453
                26784660
                d40d980b-d285-40b1-b205-d0c0c6ca49fe
                © 2013 by the authors; licensee MDPI, Basel, Switzerland.

                This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license ( http://creativecommons.org/licenses/by/3.0/).

                History
                : 16 October 2013
                : 27 November 2013
                : 28 November 2013
                Categories
                Review

                extra virgin olive oil,phenols,antioxidants,healthy,sensory
                extra virgin olive oil, phenols, antioxidants, healthy, sensory

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