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      RegGAN: A Virtual Sample Generative Network for Developing Soft Sensors with Small Data

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      ACS Omega
      American Chemical Society

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          Abstract

          Quality variables play a pivotal role in monitoring the performance of chemical production systems. However, certain critical quality variables cannot be measured online through instruments. In such scenarios, using soft sensors becomes imperative to enable real-time measurements, accurately reflecting the system’s operational status. The development of high-performance soft sensors requires abundantly labeled samples. Nevertheless, the prolonged periods and substantial costs associated with acquiring quality variable data pose challenges in obtaining sufficient labeled samples. Therefore, this paper proposes a regression generative adversarial network to generate virtual samples. The proposed method considers the mapping relationship between auxiliary and target variables while learning the data distribution. Moreover, the importance-weighted autoencoder is introduced to enhance the training stability of the generative model. The virtual samples, selected by using the similarity measurement algorithm, are incorporated into the training set. This inclusion addresses the diminished predictive performance of soft sensors when labeled samples are insufficient. The soft sensor employed in the anaerobic digestion process serves as a case study to illustrate the efficacy of the proposed generative method. Experimental results validate that the virtual samples generated by the proposed method exhibit greater proximity to the actual samples compared to those of other methods. Furthermore, integrating virtual samples into the training process of the long short-term memory-based soft sensor yields a 21.03% reduction in root-mean-square error compared with that of using the original training set alone.

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          Most cited references45

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          Generative adversarial networks

          Generative adversarial networks are a kind of artificial intelligence algorithm designed to solve the generative modeling problem. The goal of a generative model is to study a collection of training examples and learn the probability distribution that generated them. Generative Adversarial Networks (GANs) are then able to generate more examples from the estimated probability distribution. Generative models based on deep learning are common, but GANs are among the most successful generative models (especially in terms of their ability to generate realistic high-resolution images). GANs have been successfully applied to a wide variety of tasks (mostly in research settings) but continue to present unique challenges and research opportunities because they are based on game theory while most other approaches to generative modeling are based on optimization.
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            Variational Autoencoder for Generation of Antimicrobial Peptides

            Over millennia, natural evolution has allowed for the emergence of countless biomolecules with highly specific roles within natural systems. As seen with peptides and proteins, often evolution produces molecules with a similar function but with variable amino acid composition and structure but diverging from a common ancestor, which can limit sequence diversity. Using antimicrobial peptides as a model biomolecule, we train a generative deep learning algorithm on a database of known antimicrobial peptides to generate novel peptide sequences with antimicrobial activity. Using a variational autoencoder, we are able to generate a latent space plot that can be surveyed for peptides with known properties and interpolated across a predictive vector between two defined points to identify novel peptides that show dose-responsive antimicrobial activity. These proof-of-concept studies demonstrate the potential for artificial intelligence-directed methods to generate new antimicrobial peptides and motivate their potential application toward peptide and protein design without the need for exhaustive screening of sequence libraries.
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              Supervised Variational Autoencoders for Soft Sensor Modeling with Missing Data

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                Author and article information

                Journal
                ACS Omega
                ACS Omega
                ao
                acsodf
                ACS Omega
                American Chemical Society
                2470-1343
                24 January 2024
                06 February 2024
                : 9
                : 5
                : 5954-5965
                Affiliations
                Department of Control Science and Engineering, China University of Petroleum (East China) , Qingdao 266580, China
                Author notes
                Author information
                https://orcid.org/0000-0002-8635-8403
                Article
                10.1021/acsomega.3c09762
                10851387
                38343909
                d2d26bdf-ef90-4b85-915b-56dcdb418e4c
                © 2024 The Authors. Published by American Chemical Society

                Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works ( https://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 06 December 2023
                : 11 January 2024
                : 06 January 2024
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                Custom metadata
                ao3c09762
                ao3c09762

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