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      ACVIM consensus statement on diagnosis and management of acute canine thoracolumbar intervertebral disc extrusion

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          Abstract

          Background

          Thoracolumbar intervertebral disc extrusion (TL‐IVDE) is the most common cause of acute paraparesis and paraplegia in dogs; however, guidelines on management of the condition are lacking.

          Objectives

          To summarize the current literature as it relates to diagnosis and management of acute TL‐IVDE in dogs, and to formulate clinically relevant evidence‐based recommendations.

          Animals

          None.

          Methods

          A panel of 8 experts was convened to assess and summarize evidence from the peer‐reviewed literature in order to develop consensus clinical recommendations. Level of evidence available to support each recommendation was assessed and reported.

          Results

          The majority of available literature described observational studies. Most recommendations made by the panel were supported by a low or moderate level of evidence, and several areas of high need for further study were identified. These include better understanding of the ideal timing for surgical decompression, expected surgical vs medical outcomes for more mildly affected dogs, impact of durotomy on locomotor outcome and development of progressive myelomalacia, and refining of postoperative care, and genetic and preventative care studies.

          Conclusions and Clinical Importance

          Future efforts should build on current recommendations by conducting prospective studies and randomized controlled trials, where possible, to address identified gaps in knowledge and to develop cost effectiveness and number needed to treat studies supporting various aspects of diagnosis and treatment of TL‐IVDE.

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          Most cited references267

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          International Society for Companion Animal Infectious Diseases (ISCAID) guidelines for the diagnosis and management of bacterial urinary tract infections in dogs and cats

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            Eggshell apex abnormalities caused by two different Mycoplasma synoviae genotypes and evaluation of eggshell anomalies by full-field optical coherence tomography

            Background Mycoplasma synoviae (MS) is an important poultry pathogen worldwide. This bacterium may cause eggshell changes including an altered shell surface, thinning, and increased translucency in different areas, which leads to a greater incidence of eggshell cracks and breaks. In the present study the association between experimental infection of birds with two field strains of MS from different genotypes and the production of abnormal eggs is described. The analysis of those eggshells using a full-field optical coherence tomography (FF OCT) scanner is also reported. Results Eggshell samples were obtained from three experimental groups of chickens: one control and two infected tracheally with field strains of MS which produced abnormal eggs. In both experimental groups infected with MS a reduction of mean daily egg production by 11% was observed compared to the control group, which started at 21 to 42 dpi. Eggshell apex abnormalities increased to 24.5% of eggs and in some cases, soft-shelled eggs were produced. This study provides the first analysis of shells from anomalous eggs carried out using FF OCT, which allows three-dimensional structural imaging of an investigated sample at micrometre scale. FF OCT showed ultrastructural changes in eggshells and a smaller number of pores on the entire surface of the affected shells. Conclusions The eggshell pathology and the concomitant egg production losses that result from infections highlight the economic significance of MS in commercial poultry. There are differences in the strains of MS which may induce eggshell apex abnormalities (EAA) and egg production losses. The use of FF OCT, which is a noninvasive measurement method based on analysis of the light backscattered from the measured object, will confer the ability to control the quality of eggshells in flocks infected with MS.
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              FGF4 retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs

              Significance Chondrodystrophy, characterized by short limbs and intervertebral disc disease (IVDD), is a common phenotype in many of the most popular dog breeds, including the dachshund, beagle, and French bulldog. Here, we report the identification of a FGF4 retrogene insertion on chromosome 12, the second FGF4 retrogene reported in the dog, as responsible for chondrodystrophy and IVDD. Identification of the causative mutation for IVDD will impact an incredibly large proportion of the dog population and provides a model for IVDD in humans, as FGF-associated mutations are responsible for IVDD and short stature in human achondroplasia. This is a report of a second retrogene copy of the same parental gene, each causing complementary disease phenotypes in a mammalian species.
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                Author and article information

                Contributors
                njolby@ncsu.edu
                Journal
                J Vet Intern Med
                J Vet Intern Med
                10.1111/(ISSN)1939-1676
                JVIM
                Journal of Veterinary Internal Medicine
                John Wiley & Sons, Inc. (Hoboken, USA )
                0891-6640
                1939-1676
                25 July 2022
                Sep-Oct 2022
                : 36
                : 5 ( doiID: 10.1111/jvim.v36.5 )
                : 1570-1596
                Affiliations
                [ 1 ] Department of Clinical Sciences College of Veterinary Medicine, North Carolina State University Raleigh North Carolina USA
                [ 2 ] Department of Veterinary Clinical Sciences College of Veterinary Medicine, The Ohio State University Columbus Ohio USA
                [ 3 ] Department of Clinical Studies Ontario Veterinary College, Ontario Veterinary College Guelph Ontario Canada
                [ 4 ] Department of Clinical Science and Services Royal Veterinary College London United Kingdom
                [ 5 ] Department for Small Animals Leipzig University Leipzig Germany
                [ 6 ] VCA Sacramento Veterinary Referral Center Sacramento California USA
                [ 7 ] Department of Veterinary Clinical Sciences Purdue University West Lafayette Indiana USA
                [ 8 ] University of Veterinary Medicine Hanover Hanover Germany
                Author notes
                [*] [* ] Correspondence

                Natasha J. Olby, North Carolina State University, 1060 William Moore Dr, Raleigh, NC 27607, USA.

                Email: njolby@ 123456ncsu.edu

                Author information
                https://orcid.org/0000-0003-1349-3484
                https://orcid.org/0000-0002-4311-6199
                https://orcid.org/0000-0002-9646-0815
                https://orcid.org/0000-0001-7851-670X
                https://orcid.org/0000-0001-9892-0224
                https://orcid.org/0000-0001-6643-191X
                https://orcid.org/0000-0002-9421-942X
                Article
                JVIM16480
                10.1111/jvim.16480
                9511077
                35880267
                cffa3913-8795-4b56-9c87-05a2e2ef2cb8
                © 2022 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

                History
                : 26 May 2022
                : 12 June 2022
                Page count
                Figures: 1, Tables: 12, Pages: 27, Words: 22933
                Categories
                Consensus Statement
                Consensus Statement
                Custom metadata
                2.0
                September/October 2022
                Converter:WILEY_ML3GV2_TO_JATSPMC version:6.1.9 mode:remove_FC converted:26.09.2022

                Veterinary medicine
                dog,intervertebral disc herniation,paralysis,spinal cord injury
                Veterinary medicine
                dog, intervertebral disc herniation, paralysis, spinal cord injury

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