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      The Evaluation and Followup of Children Referred to Pediatric Endocrinologists for Short Stature

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          Abstract

          Objective. To characterize the pediatric endocrinologists' evaluation and followup of short-statured patients. Study Design. Observational study of 21,548 short-statured children (April 1996 to December 1999). Baseline demographics, laboratory testing, height standard deviation score (SDS), target height, and height relative to target height were analyzed at initial and return visits with the specialist. Patients were scheduled for at least one return visit and no recombinant human growth hormone therapy was administered. Results. Mean patient age was 8.6 years with a mean height SDS of −2.1. Patients were predominantly male (69%), prepubertal (73%), and white (76%). Few screening tests were obtained during initial evaluation. Nearly 40% of children did not return for their second scheduled visit. The follow-up rate was unrelated to demographics or degree of short stature. Conclusions. Low return rates limit specialists' ability to monitor growth or obtain laboratory testing over time. Further studies are needed to determine which tests should be obtained at the initial clinic visit as well as the basis for the low return rate in this group of children.

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          Most cited references18

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          Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. GH Research Society.

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            Clinical longitudinal standards for height and height velocity for North American children.

            Longitudinally-based height and height velocity charts for North American children are presented. Centiles are given for early, middle, and late maturers. The shape of the curves is taken from a review of longitudinal studies, and the prepubertal and adult centiles for height attained are taken from National Center for Health Statistics data. The charts are suitable for following an individual child's progress during observation or treatment throughout the growth period, including puberty.
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              Recommendations for the diagnosis and management of Turner syndrome.

              Comprehensive recommendations on the diagnosis of Turner syndrome (TS) and the care of affected individuals were published in 1994. In the light of recent advances in diagnosis and treatment of TS, an international multidisciplinary workshop was convened in March 2000, in Naples, Italy, in conjunction with the Fifth International Symposium on Turner Syndrome to update these recommendations. The present paper details the outcome from this workshop. The genetics and diagnosis of the syndrome are described, and practical treatment guidelines are presented.
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                Author and article information

                Journal
                Int J Pediatr Endocrinol
                IJPE
                International Journal of Pediatric Endocrinology
                Hindawi Publishing Corporation
                1687-9848
                1687-9856
                2010
                24 June 2010
                : 2010
                : 652013
                Affiliations
                1Medical College of Wisconsin, 9000 West Wisconsin Avenue, MC C520, P.O. Box 1997, Milwaukee, WI 53201-1997, USA
                2Morehouse School of Medicine, 720 Westview Drive South West, Atlanta, GA 30310-1495, USA
                3University of Arkansas for Medical Sciences, Arkansas Children's Hospital 1 Children's Way, 4301 West Markham Street, Little Rock, AR 72205, USA
                4Genentech, Inc., Stanford University Medical Center, 1 DNA Way, South San Francisco, CA 94080, USA
                5Medical Science Liaison, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA
                Author notes

                Academic Editor: Michael Bernd Ranke

                Article
                10.1155/2010/652013
                2905720
                20652081
                cdb525be-7772-40a1-b2e8-fa109a4613c6
                Copyright © 2010 David Wyatt et al.

                This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 22 December 2009
                : 30 March 2010
                : 22 April 2010
                Categories
                Research Article

                Pediatrics
                Pediatrics

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