A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise.

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Abstract

Early subtle deficits in verbal memory, which may indicate early neural risk, are common in patients with coronary artery disease (CAD). While exercise can improve cognition, cognitive response to exercise is heterogeneous. Sphingolipids have been associated with the development and progression of CAD, and impairments in sphingolipid metabolism may play roles in neurodegeneration and in the neural adaptation response to exercise.

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Journal

Journal ID (iso-abbrev): J. Alzheimers Dis.

Title: Journal of Alzheimer's disease : JAD

Publisher: IOS Press

ISSN (Electronic): 1875-8908

ISSN (Print): 1387-2877

Publication date (Electronic): 2017

Volume: 60

Issue: 3

Affiliations

[1 ] Neuropsychopharmacology Research Group, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

[2 ] Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

[3 ] Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

[4 ] Departments of Neurology and Health Sciences Research, Mayo Clinic, Rochester, MN, USA.

[5 ] Division of Clinical Pharmacology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

[6 ] Toronto Rehabilitation Institute, Toronto, ON, Canada.

[7 ] Neuropsychology, Sunnybrook HealthSciences Centre, Toronto, ON, Canada.

[8 ] Evaluative Clinical Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

[9 ] Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

[10 ] Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Article

Publisher Item ID: JAD161292 Mid ID: NIHMS926919

DOI: 10.3233/JAD-161292

PMC ID: 5753402

PubMed ID: 28598843

SO-VID: cd99c3dc-333b-4ca3-9c65-4b2cc33edc56

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Keywords: cognition,sphingolipids,memory,exercise,coronary artery disease,Ceramides

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Keywords: cognition, sphingolipids, memory, exercise, coronary artery disease, Ceramides

A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise.

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