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      Acute Cholecystitis in a Patient With Situs Inversus Totalis: An Unexpected Finding

      case-report

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          Abstract

          Situs inversus totalis (SIT) has an incidence in the general population of 1/10,000, with a female-male ratio of 1:1.5 without racial predilection. Clinically, SIT by itself tends to be asymptomatic; however, when it is associated with other conditions such as cholecystitis or appendicitis, the diagnosis may represent a challenge due to the reversed anatomical location of symptoms.

          This article presents a case of a 46-year-old female who arrived at the emergency department due to one week of non-bilious vomiting and colicky abdominal pain located in the left hypochondrium; therefore, abdominal ultrasonography was performed, showing transposition of abdominal organs associated with cholelithiasis plus acute cholecystitis. As a result, the patient was scheduled for laparoscopic cholecystectomy, resulting in an appropriate post-surgical evolution, for which discharge was given with a general surgery control appointment.

          Laparoscopic cholecystectomy in patients with SIT represents a challenge due to the technical complexity derived from the transposition of the abdominal organs; therefore, the surgeon is forced to perform the procedure by placing three trocars with a specular approach plus the umbilical trocar.

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          Most cited references19

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          Abdominal manifestations of situs anomalies in adults.

          A study was made of 19 adults with situs anomalies (situs inversus [n = 10], situs ambiguous with polysplenia [n = 8], situs ambiguous with asplenia [n = 1]). No patient had congenital heart disease, bowel obstruction related to malrotation, or immune deficiency disorders. All 10 patients with situs inversus had mirror-image location of the abdominal organs relative to situs solitus; nine had dextrocardia, and one had levocardia. The eight adults with situs ambiguous with polysplenia demonstrated a spectrum of abnormalities. All had some degree of abdominal heterotaxy, including midline livers and gallbladders (n = 5), right-sided stomachs and spleens (n = 3), and rotational abnormalities of the small bowel and colon (n = 7). Other findings included multiple spleens (n = 7), interruption of the inferior vena cava (IVC) with azygous or hemiazygous continuation (n = 7), truncation of the pancreas (n = 6), and ipsilateral location of the aorta and IVC (n = 1). In the one patient with asplenia, a midline liver, right-sided stomach, bowel rotation abnormality, IVC interruption, and pancreatic truncation were noted. Recognition of the spectrum of situs anomalies is important because the altered anatomy associated with these anomalies may result in confusing imaging findings when seen in conjunction with acquired diseases. Copyright RSNA, 2002
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            Clinical aspects of defects in the determination of laterality.

            Of individuals in the human population, 99.99% have developed identical thoracoabdominal asymmetry with the cardiac apex, a bilobed lung, the stomach, and the spleen on the left side of the midline, and the vena cavae, a trilobed lung, the appendix, and the larger liver lobe on the right. This arrangement of organs is situs solitus. Occasionally, individuals have a complete, mirror-image reversal of this asymmetry called situs inversus, and 20-25% of those individuals have an autosomal recessive condition, Kartagener syndrome, with ciliary dyskinesia, bronchiectasis, sinusitis, and infertility. Between these extremes of situs solitus and situs inversus lies the spectrum of situs ambiguus, characterized by isomerism, heterotaxy, and multiple malformations in one or more thoracic or abdominal organs. Although most abnormal situs in humans occurs sporadically, growing evidence suggests that interference with normal genetic mechanisms and pathways may be responsible for most cases. Familial cases suggest major effects of both autosomal and X-linked genes with both dominant and recessive expression. Situs inversus and situs ambiguus (SI/SA) occurring in probands who have close relatives with "isolated," nonsyndromic birth defects suggests that some of the pathways important in situs determination may also be involved in causing sporadic malformations not obviously associated with a defect in laterality determination. Human phenotypes of interest include the association of SI/SA with short rib-polydactyly syndromes and renal-hepatic-pancreatic dysplasia, and with agnathia and holoprosencephaly. Further elucidation of the developmental pathways involved in left-right axis determination should shed light on the causes of and relationships among these human phenotypes. Copyright 2001 Wiley-Liss, Inc.
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              Laparoscopic cholecystectomy in situs inversus totalis: Feasibility and review of literature.

              Situs inversus totalis is a rare anomaly characterized by transposition of organs to the opposite site of the body. Laparoscopic cholecystectomy in those patients is technically more demanding and needs reorientation of visual-motor skills to left upper quadrant.
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                Author and article information

                Journal
                Cureus
                Cureus
                2168-8184
                Cureus
                Cureus (Palo Alto (CA) )
                2168-8184
                21 June 2021
                June 2021
                : 13
                : 6
                : e15799
                Affiliations
                [1 ] Radiology, Universidad El Bosque, Bogotá D.C., COL
                [2 ] Surgery, Clínica del Country, Bogotá D.C., COL
                [3 ] Surgery, Universidad del Rosario, Bogotá D.C., COL
                [4 ] Surgery, Universidad Nacional, Bogotá D.C., COL
                Author notes
                Andres Felipe Herrera Ortiz afherreraor@ 123456gmail.com
                Article
                10.7759/cureus.15799
                8294112
                34306867
                cd88a216-de5b-4368-a668-8a27ed4ccea9
                Copyright © 2021, Herrera Ortiz et al.

                This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

                History
                : 21 June 2021
                Categories
                Gastroenterology
                General Surgery

                cholecystectomy laparoscopic,situs inversus,cholecystitis,cholelithiasis,abdominal pain

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