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An outbreak of Shiga toxin-producing Escherichia coli O104:H4 hemolytic uremic syndrome in Germany: presentation and short-term outcome in children.
Sebastian Loos
1 ,
Thurid Ahlenstiel ,
Brigitta Kranz ,
Hagen Staude ,
Lars Pape ,
Christoph Härtel ,
Udo Vester ,
Laura Buchtala ,
Kerstin Benz ,
Bernd Hoppe ,
Ortraud Beringer ,
Martin Krause ,
Dominik Müller ,
Martin Pohl ,
Johanna Lemke ,
Georg Hillebrand ,
Martin Kreuzer ,
Jens König ,
Marianne Wigger ,
Martin Konrad ,
Dieter Haffner ,
Jun Oh ,
Markus J Kemper
Sep 2012
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Abstract
In May and June 2011 the largest known outbreak of hemolytic uremic syndrome (HUS) occurred in northern Germany. Because, quite unusually, a large number of adults was affected and the causative Escherichia coli strain, serotype O104:H4, showed an atypical virulence factor pattern, it was speculated that this outbreak was associated with an aggressive course and an unfavorable prognosis also in children.