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      A versatile drug delivery system using streptavidin-tagged pegylated liposomes and biotinylated biomaterials.

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          Abstract

          Here we have developed a versatile liposome-mediated drug delivery system (DDS) allowing a strong bridge between the streptavidin-tagged liposome (SAL) and biotin (Bi)-tagged biomaterials which has strong affinity to surface proteins expressed in restricted cell lineages. This DDS was effective and specific for many leukemia cells in vitro and in vivo. When examining 6 human leukemia cell lines using calcein-encapsulated SALs in combination with Bi-granulocyte colony-stimulating factor (G-CSF), Bi-anti-CD33 monoclonal antibody (MAb) or Bi-anti-CD7 MAb, the fluorescent positive rate of each cell line was in almost proportion to degree of G-CSF receptor, CD33 or CD7 expression, respectively. More importantly, the binding ability was shown to be well maintained in a mouse xenograft model. Furthermore the cytosine arabinoside (AraC)-encapsulated SALs could kill the corresponding cells much more effectively in combination with Bi-biomaterials than free AraC, as expected. These findings strongly indicate that our SAL/Bi-biomaterial system could allow various types of medical agents to be delivered reliably and stably to the cells targeted.

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          Author and article information

          Journal
          Int J Pharm
          International journal of pharmaceutics
          Elsevier BV
          1873-3476
          0378-5173
          Sep 15 2013
          : 454
          : 1
          Affiliations
          [1 ] Department of Medicine, National Yang-Ming University Hospital, I-Lan, Taiwan.
          Article
          S0378-5173(13)00540-1
          10.1016/j.ijpharm.2013.06.031
          23806815
          c9e5b4ae-3256-4767-86d4-2590b3c55b1b
          History

          Tumor-targeting,Streptavidin,Internalization,Immunoliposome,Drug delivery system,Biotin

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