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      Sistemas osmóticos de administración oral Translated title: Osmotically controlled oral drug delivery systems

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          Abstract

          Considerando que en el ámbito mundial el diseño de nuevos fármacos involucra un costo muy alto, tanto en tiempo como en dinero, la preocupación en los años recientes se ha centrado en diseñar y desarrollar medicamentos que controlen la liberación del activo, de manera que se les pueda dar un valor agregado a moléculas ya existentes, lo que significa una menor inversión en términos de costos. En este sentido, para la presente revisión se seleccionó el sistema de liberación osmótica, uno de los medicamentos de liberación controlada con más participación en el mercado en el mundo. En este escrito se muestran los aspectos fisicoquímicos relacionados con su formulación, las clases de sistemas osmóticos de administración oral existentes y sus aplicaciones, así como el estado del arte en este contexto. Hacia el futuro, estos sistemas osmóticos parecen ser muy promisorios, debido a sus ventajas y gran mercado potencial.

          Translated abstract

          In recent years, the worldwide, the attention has been focused on the development of new drug products with controlled delivery. The reason for this new tendency is relatively low cost and time required to development this kind of product as compared to a new drug. In this sense, the osmotic systems, controlled delivery drug products, have been chosen for the present review to illustrate their physicochemical principles that govern their formulation. Different types of oral osmotic systems and their applications are also discussed. Finally, some studies related to this subject were reviewed. Because of their advantages and strong market potential, the future of osmotic systems seems so good.

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          Most cited references44

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          Formulation aspects in the development of osmotically controlled oral drug delivery systems.

          Osmotically controlled oral drug delivery systems utilize osmotic pressure for controlled delivery of active agent(s). Drug delivery from these systems, to a large extent, is independent of the physiological factors of the gastrointestinal tract and these systems can be utilized for systemic as well as targeted delivery of drugs. The release of drug(s) from osmotic systems is governed by various formulation factors such as solubility and osmotic pressure of the core component(s), size of the delivery orifice, and nature of the rate-controlling membrane. By optimizing formulation and processing factors, it is possible to develop osmotic systems to deliver drugs of diverse nature at a pre-programmed rate. In the present review, different types of oral osmotic systems, various aspects governing drug release from these systems, and critical formulation factors are discussed.
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            Osmotic drug delivery: a review of the patent literature

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              A water-insoluble drug monolithic osmotic tablet system utilizing gum arabic as an osmotic, suspending and expanding agent.

              A monolithic osmotic tablet system (MOTS) with two orifices in both side surfaces has been studied. Water-insoluble naproxen was selected as the model drug. Gum arabic was used as an osmotic, suspending and expanding agent, and cellulose acetate (CA) was used as semipermeable membrane. Polyethylene glycol 400 (PEG-400) was employed as plasticizer for controlling membrane porosity. The influences of gum arabic, PEG-400, membrane thickness and orifice size on the naproxen release profiles were investigated, and the optimal MOTS was evaluated in different environment media and stirring rates. The optimal MOTS was found to be able to deliver naproxen at a rate of approximately zero order up to 12 h in pH 6.8, cumulative release at 12 h is 81%, independent on environment media and stirring rate. Therefore, this MOTS can be used in oral drug-controlled delivery field, especially for water-insoluble drug.
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                Author and article information

                Journal
                rccqf
                Revista Colombiana de Ciencias Químico - Farmacéuticas
                Rev. colomb. cienc. quim. farm.
                Departamento de Farmácia, Facultad de Ciencias, Universidade Nacional da Colombia (Bogotá, Distrito Capital, Colombia )
                0034-7418
                1909-6356
                June 2006
                : 35
                : 2
                : 192-211
                Affiliations
                [03] orgnameUniversidad Nacional de Colombia lfponced@ 123456unal.edu.co
                [02] Bogotá D.C orgnameUniversidad Nacional de Colombia orgdiv1Departamento de Farmacia Colombia
                [01] orgnameUniversidad Nacional de Colombia ybaenaa@ 123456unal.edu.co
                Article
                S0034-74182006000200004 S0034-7418(06)03500204
                c8ee9dc4-c40a-407e-b576-2723e5c047de

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                : 18 December 2006
                : 10 October 2006
                Page count
                Figures: 0, Tables: 0, Equations: 0, References: 44, Pages: 20
                Product

                SciELO Colombia

                Self URI: Texto completo solamente en formato PDF (ES)

                bomba osmótica,sistema osmótico,presión osmótica,sistema de liberación modificada,administración oral,osmotic pump,osmotic system,osmotic pressure,modified release system,oral administration

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