Contributors
Sarah J. Garnai:
ORCID: http://orcid.org/0000-0002-0283-5437
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
Writing – original draftRole: Writing – review & editing
Michelle L. Brinkmeier: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: InvestigationRole:
MethodologyRole: Writing – original draftRole: Writing – review & editing
Ben Emery: Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: ResourcesRole: Writing – original draftRole: Writing – review &
editing
Tomas S. Aleman: Role: Data curationRole: InvestigationRole: ResourcesRole: Writing – review & editing
Louise C. Pyle:
ORCID: http://orcid.org/0000-0002-8933-9320
Role: InvestigationRole: ResourcesRole: Writing – review & editing
Biliana Veleva-Rotse:
ORCID: http://orcid.org/0000-0002-7783-0112
Role: InvestigationRole: Resources
Robert A. Sisk: Role: Data curationRole: InvestigationRole: ResourcesRole: Writing – original draft
Frank W. Rozsa: Role: Project administrationRole: ResourcesRole: Writing – review & editing
Ayse Bilge Ozel: Role: MethodologyRole: ResourcesRole: Software
Jun Z. Li: Role: InvestigationRole: MethodologyRole: Software
Sayoko E. Moroi: Role: Resources
Steven M. Archer:
ORCID: http://orcid.org/0000-0002-5539-4129
Role: ResourcesRole: Writing – review & editing
Cheng-mao Lin:
ORCID: http://orcid.org/0000-0003-2409-9423
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Sarah Sheskey:
ORCID: http://orcid.org/0000-0003-3394-4174
Role: InvestigationRole: MethodologyRole: Writing – review & editing
Laurel Wiinikka-Buesser: Role: Data curationRole: InvestigationRole: Resources
James Eadie: Role: Investigation
Jill E. Urquhart: Role: Investigation
Graeme C.M. Black: Role: Funding acquisitionRole: InvestigationRole: SupervisionRole: Writing – review
& editing
Mohammad I. Othman: Role: Investigation
Michael Boehnke:
ORCID: http://orcid.org/0000-0002-6442-7754
Role: Resources
Scot A. Sullivan: Role: Resources
Gregory L. Skuta: Role: Resources
Hemant S. Pawar: Role: Data curationRole: Formal analysisRole: Investigation
Alexander E. Katz:
ORCID: http://orcid.org/0000-0001-9706-9490
Role: Resources
Laryssa A. Huryn: Role: InvestigationRole: Writing – review & editing
Robert B. Hufnagel: Role: InvestigationRole: ResourcesRole: Writing – review & editing
Sally A. Camper:
ORCID: http://orcid.org/0000-0001-8556-3379
Role: ConceptualizationRole: Formal analysisRole: Funding acquisitionRole: MethodologyRole:
Project administrationRole: SupervisionRole: Writing – review & editing
Julia E. Richards: Role: ConceptualizationRole: Funding acquisitionRole: MethodologyRole: Project administrationRole:
SupervisionRole: Writing – review & editing
Lev Prasov:
ORCID: http://orcid.org/0000-0002-6635-1116
Role: ConceptualizationRole: Data curationRole: Formal analysisRole: Funding acquisitionRole:
InvestigationRole: MethodologyRole: Project administrationRole: SupervisionRole: Writing
– original draftRole: Writing – review & editing
Michael G. Anderson: Role: Editor
Journal
Journal ID (nlm-ta): PLoS Genet
Journal ID (iso-abbrev): PLoS Genet
Journal ID (publisher-id): plos
Journal ID (pmc): plosgen
Title:
PLoS Genetics
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7390
ISSN
(Electronic):
1553-7404
Publication date
(Electronic):
2
May
2019
Publication date Collection:
May
2019
Volume: 15
Issue: 5
Electronic Location Identifier: e1008130
Affiliations
[1
]
Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University
of Michigan, Ann Arbor, MI, United States of America
[2
]
Harvard Medical School, Boston, MA, United States of America
[3
]
Department of Human Genetics, University of Michigan, Ann Arbor, MI, United States
of America
[4
]
Jungers Center for Neurosciences Research, Department of Neurology, Oregon Health
& Science University, Portland, OR, United States of America
[5
]
The Children’s Hospital of Philadelphia, Philadelphia, PA, United States of America
[6
]
Scheie Eye Institute, Department of Ophthalmology, Philadelphia, PA, United States
of America
[7
]
Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA,
United States of America
[8
]
Cincinnati Eye Institute, Cincinnati, Ohio, United States of America
[9
]
Molecular and Behavior Neuroscience Institute, University of Michigan, Ann Arbor,
MI, United States of America
[10
]
Manchester Centre for Genomic Medicine, Manchester Academic Health Sciences Centre,
Manchester University NHS Foundation Trust, St Mary’s Hospital, Manchester, United
Kingdom
[11
]
Division of Evolution and Genomic Sciences, Faculty of Biology, Medicine and Health,
University of Manchester, Manchester, United Kingdom
[12
]
Department of Biostatistics and Center for Statistical Genetics, University of Michigan,
Ann Arbor, MI, United States of America
[13
]
Dean McGee Eye Institute, Department of Ophthalmology, University of Oklahoma, Oklahoma
City, OK
[14
]
Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute,
National Institutes of Health, Bethesda, MD, United States of America
[15
]
Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes
of Health, Bethesda, MD, United States of America
[16
]
Department of Epidemiology, University of Michigan, Ann Arbor, MI, United States of
America
University of Iowa, UNITED STATES
Author notes
The authors have declared that no competing interests exist.
¶ Membership of the Genomic Ascertainment Cohort is listed in the Acknowledgments.
Author information
Article
Publisher ID:
PGENETICS-D-18-02347
DOI: 10.1371/journal.pgen.1008130
PMC ID: 6527243
PubMed ID: 31048900
SO-VID: c8e69d0c-1775-42d3-9e59-ecacc99efcc0
License:
This is an open access article, free of all copyright, and may be freely reproduced,
distributed, transmitted, modified, built upon, or otherwise used by anyone for any
lawful purpose. The work is made available under the
Creative Commons CC0 public domain dedication.
History
Date
received
: 11
December
2018
Date
accepted
: 9
April
2019
Page count
Figures: 10,
Tables: 0,
Pages: 36
Funding
Funded by: funder-id http://dx.doi.org/10.13039/100001209, Knights Templar Eye Foundation;
Award Recipient
:
ORCID: http://orcid.org/0000-0002-6635-1116
Lev Prasov
Funded by: funder-id http://dx.doi.org/10.13039/100001818, Research to Prevent Blindness;
Award Recipient
:
Julia E. Richards
Funded by: funder-id http://dx.doi.org/10.13039/100000053, National Eye Institute;
Award ID: P30 EY007003
Funded by: funder-id http://dx.doi.org/10.13039/100001818, Research to Prevent Blindness;
Award ID: Unrestricted Award to DMEI
Funded by: funder-id http://dx.doi.org/10.13039/100006108, National Center for Advancing Translational Sciences;
Award ID: KL2TR001879-03
Award Recipient
:
ORCID: http://orcid.org/0000-0002-8933-9320
Louise C. Pyle
Funded by: Race to Erase MS
Award Recipient
:
Ben Emery
Funded by: funder-id http://dx.doi.org/10.13039/501100000310, RP Fighting Blindness;
Award Recipient
:
Graeme C.M. Black
Funded by: funder-id http://dx.doi.org/10.13039/501100000615, Fight for Sight UK;
Award ID: GR586
Award Recipient
:
Graeme C.M. Black
Funded by: funder-id http://dx.doi.org/10.13039/100000053, National Eye Institute;
Award ID: Intramural funds
Award Recipient
:
Laryssa A. Huryn
Funded by: funder-id http://dx.doi.org/10.13039/100000002, National Institutes of Health;
Award ID: Director's Challenge Fund
L.P. was supported by the Knights Templar Eye Foundation Career Starter Award, the
Alliance for Vision Research Award, and the Michigan Ophthalmology Trainee Career
Development Award. C.M.L. and S.S. were supported by the National Eye Institute Vision
Core Grant P30 EY007003 (University of Michigan). J.E.R. was supported by National
Eye Institute grants EY09580 and EY11671, by the Research to Prevent Blindness unrestricted
grant to the W.K. Kellogg Eye Center/University of Michigan, and by the Midwest Eye
Bank. B.E. was supported by the National Multiple Sclerosis Society grant RG 5106A1,
the Warren Endowed professorship in Neuroscience Research, and Race to Erase MS. L.C.P.
was supported by a grant from the National Center for Advancing Translational Sciences
KL2-TR000187903. R.B.H, L.A.H, and L.P. were also supported by National Eye Institute
Intramural Funds. TGAC and A.E.K. were supported by the National Institutes of Health
Director Challenge Fund. G.C.M.B. was supported by Retina UK/RP Fighting Blindness
and Fight for Sight (RP Genome Project GR586) and by the NIHR Manchester BRC. G.L.S.
was supported by Research to Prevent Blindness Unrestricted Grant to Dean McGee Eye
Institute/University of Oklahoma. The funders had no role in study design, data collection
and analysis, decision to publish or preparation of the manuscript. The funders had
no role in study design, data collection and analysis, decision to publish or preparation
of the manuscript.
Categories
Subject:
Research Article
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Eyes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Head
Subject:
Eyes
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Biology and Life Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Eyes
Subject:
Medicine and Health Sciences
Subject:
Anatomy
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Ocular System
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Eyes
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Research and Analysis Methods
Subject:
Animal Studies
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Experimental Organism Systems
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Model Organisms
Subject:
Mouse Models
Subject:
Research and Analysis Methods
Subject:
Animal Studies
Subject:
Experimental Organism Systems
Subject:
Animal Models
Subject:
Mouse Models
Subject:
Medicine and Health Sciences
Subject:
Ophthalmology
Subject:
Retinal Disorders
Subject:
Retinal Degeneration
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Ocular System
Subject:
Ocular Anatomy
Subject:
Retina
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Medicine and Health Sciences
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Anatomy
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Ocular System
Subject:
Ocular Anatomy
Subject:
Retina
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Biology and Life Sciences
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Genetics
Subject:
Heredity
Subject:
Genetic Mapping
Subject:
Haplotypes
Subject:
Biology and Life Sciences
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Cell Biology
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Cellular Types
Subject:
Animal Cells
Subject:
Neurons
Subject:
Afferent Neurons
Subject:
Photoreceptors
Subject:
Biology and Life Sciences
Subject:
Neuroscience
Subject:
Cellular Neuroscience
Subject:
Neurons
Subject:
Afferent Neurons
Subject:
Photoreceptors
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Biology and Life Sciences
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Neuroscience
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Sensory Perception
Subject:
Sensory Receptors
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Photoreceptors
Subject:
Biology and Life Sciences
Subject:
Psychology
Subject:
Sensory Perception
Subject:
Sensory Receptors
Subject:
Photoreceptors
Subject:
Social Sciences
Subject:
Psychology
Subject:
Sensory Perception
Subject:
Sensory Receptors
Subject:
Photoreceptors
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Signal Transduction
Subject:
Sensory Receptors
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Photoreceptors
Subject:
Biology and Life Sciences
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Anatomy
Subject:
Animal Anatomy
Subject:
Animal Ocular Anatomy
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Animal Anatomy
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Animal Ocular Anatomy
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Biology and Life Sciences
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Zoology
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Animal Anatomy
Subject:
Animal Ocular Anatomy
Subject:
Biology and Life Sciences
Subject:
Molecular Biology
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
Subject:
Research and Analysis Methods
Subject:
Molecular Biology Techniques
Subject:
Artificial Gene Amplification and Extension
Subject:
Polymerase Chain Reaction
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