Antitumor Effects of Lidocaine on Human Breast Cancer Cells: An In Vitro and In Vivo Experimental Trial.

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Abstract

Retrospective studies have suggested a protective effect of regional anesthesia against recurrence after cancer surgery. But confirmation of the in vivo antitumor effects is lacking. We examined the in vitro antitumor effects of lidocaine on various breast cancer cell lines and then assessed these properties in vivo at clinically relevant concentrations.

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Journal

Journal ID (iso-abbrev): Anticancer Res.

Title: Anticancer research

Publisher: International Institute of Anticancer Research

ISSN (Electronic): 1791-7530

ISSN (Print): 0250-7005

Publication date (Electronic): January 2018

Volume: 38

Issue: 1

Affiliations

[1 ] Department of Anesthesiology and Surgical Intensive Care, Hautepierre Hospital, CHRU, University Hospital of Strasbourg, Strasbourg, France chamarau@igbmc.fr.

[2 ] Functional Genomics and Cancer Department, Institute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch, France.

[3 ] French National Center for Scientific Research (CNRS) UMR7104, Illkirch, France.

[4 ] French National Institute of Health and Medical Research (INSERM) U964, Illkirch, France.

[5 ] Faculty of Medicine, University of Strasbourg, Strasbourg, France.

[6 ] Department of Gynecology and Obstetrics, Hautepierre Hospital, CHRU, University Hospital of Strasbourg, Strasbourg, France.

[7 ] Research Institute against Digestive Cancer - European Institute of TeleSurgery (IRCAD), Strasbourg, France.

[8 ] Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, TX, U.S.A.

[9 ] Department of Anesthesiology and Surgical Intensive Care, Hautepierre Hospital, CHRU, University Hospital of Strasbourg, Strasbourg, France.

Article

Publisher Item ID: 38/1/95

DOI: 10.21873/anticanres.12196

PubMed ID: 29277761

SO-VID: c7a80015-c918-41b8-b08c-ebe7cce43ae4

History

Keywords: MDA-MB-231 cell line,xenograft model antitumor assays,lidocaine,breast cancer,Local anesthetics

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Keywords: MDA-MB-231 cell line, xenograft model antitumor assays, lidocaine, breast cancer, Local anesthetics

Antitumor Effects of Lidocaine on Human Breast Cancer Cells: An In Vitro and In Vivo Experimental Trial.

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Karger: Oncology

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