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      Periodontitis and non-communicable diseases in a Brazilian population, a cross-sectional study, Vila Velha-ES, Brazil

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          Abstract

          Objectives

          The objective of this study was to examine the hypothesis that periodontal disease is associated with chronic non-communicable diseases.

          Methods

          In this cross-sectional study, we evaluated the periodontal health condition of the population, based on the community periodontal index, as well as the number of missing teeth and the presence of systemic health conditions. We quantified the association between oral health and the presence of chronic diseases using simple logistic regression, adjusting for confounding factors including age, smoking, and overweight.

          Results

          The study population consisted of 334 volunteers, aged between 19 and 81 years. In patients over 45 years old, periodontal disease was found to be significantly associated with hypertension and diabetes. Furthermore, in female patients, periodontal disease was significantly associated with hypertension, diabetes, and cancer.

          Conclusion

          Our findings indicate that periodontal disease is positively and significantly associated with both arterial hypertension and diabetes, independent of potential confounding factors.

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          Most cited references33

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          Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

          Periodontitis, a major inflammatory disease of the oral mucosa, is epidemiologically associated with other chronic inflammation-driven disorders, including cardio-metabolic, neurodegenerative and autoimmune diseases and cancer. Emerging evidence from interventional studies indicates that local treatment of periodontitis ameliorates surrogate markers of comorbid conditions. The potential causal link between periodontitis and its comorbidities is further strengthened by recent experimental animal studies establishing biologically plausible and clinically consistent mechanisms whereby periodontitis could initiate or aggravate a comorbid condition. This multi-faceted ‘mechanistic causality’ aspect of the link between periodontitis and comorbidities is the focus of this Review. Understanding how certain extra-oral pathologies are affected by disseminated periodontal pathogens and periodontitis-associated systemic inflammation, including adaptation of bone marrow haematopoietic progenitors, may provide new therapeutic options to reduce the risk of periodontitis-associated comorbidities.
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            The role of the microbiota in periodontal disease

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              The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: a meta-analysis.

              Previous studies have shown conflicting results as to whether periodontitis (PD) is associated with increased risk of coronary heart disease (CHD). The aim of the current study was to evaluate whether such an association exists. A systematic review of the literature revealed 5 prospective cohort studies (follow-up >6 years), 5 case-control studies, and 5 cross-sectional studies that were eligible for meta-analysis. Individual studies were adjusted for confounding factors such as age, sex, diabetes mellitus, and smoking. The 3 study categories were analyzed separately. Heterogeneity of the studies was assessed by Cochran Q test. The studies were homogeneous; therefore, the Mantel-Haenszel fixed-effect model was used to compute common relative risk and odds ratio (OR). Meta-analysis of the 5 prospective cohort studies (86092 patients) indicated that individuals with PD had a 1.14 times higher risk of developing CHD than the controls (relative risk 1.14, 95% CI 1.074-1.213, P < .001). The case-control studies (1423 patients) showed an even greater risk of developing CHD (OR 2.22, 95% CI 1.59-3.117, P < .001). The prevalence of CHD in the cross-sectional studies (17724 patients) was significantly greater among individuals with PD than in those without PD (OR 1.59, 95% CI 1.329-1.907, P < .001). When the relationship between number of teeth and incidence of CHD was analyzed, cohort studies showed 1.24 times increased risk (95% CI 1.14-1.36, P < .0001) of development of CHD in patients with <10 teeth. This meta-analysis indicates that both the prevalence and incidence of CHD are significantly increased in PD. Therefore, PD may be a risk factor for CHD. Prospective studies are required to prove this assumption and evaluate risk reduction with the treatment of PD.
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                Author and article information

                Journal
                Osong Public Health Res Perspect
                Osong Public Health Res Perspect
                PHRP
                Osong Public Health and Research Perspectives
                Korea Disease Control and Prevention Agency
                2210-9099
                2233-6052
                June 2024
                27 June 2024
                : 15
                : 3
                : 212-220
                Affiliations
                [1 ]Postgraduate Program in Infectious Diseases, Federal University of Espírito Santo, Vitória, Brazil
                [2 ]Department of Social Medicine, Federal University of Espírito Santo, Vitória, Brazil
                [3 ]Department of Dentistry, Federal University of Espírito Santo, Vitória, Brazil
                [4 ]Postgraduate Program in Dental Sciences, Federal University of Espírito Santo, Vitória, Brazil
                [5 ]Santa Casa de Misericórdia School of Medicine, Vitória, Brazil
                Author notes
                Corresponding author: Gustavo Vital de Mendonça Postgraduate Program in Infectious Diseases, Federal University of Espírito Santo, Av. Mal. Campos, 1468-Santa Cecília, Vitória-ES 29047-100, Brazil E-mail: drgustavo.mendonca@ 123456gmail.com
                Author information
                http://orcid.org/0000-0002-4314-9708
                http://orcid.org/0000-0002-9485-4191
                http://orcid.org/0000-0003-4090-4760
                http://orcid.org/0000-0002-8901-7380
                http://orcid.org/0000-0002-1240-4008
                Article
                j-phrp-2024-0021
                10.24171/j.phrp.2024.0021
                11237320
                38988024
                c64eedeb-5f2d-45b0-90fc-be3f79ed5d21
                © 2024 Korea Disease Control and Prevention Agency.

                This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                : 17 January 2024
                : 11 April 2024
                : 16 April 2024
                Categories
                Original Article

                chronic disease,cross-sectional studies,diabetes mellitus,health services research,hypertension,periodontitis

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