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Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome
Siamak MahmoudianDehkordi ,
Matthias Arnold ,
Kwangsik Nho ,
Shahzad Ahmad ,
Wei Jia ,
Guoxiang Xie ,
Gregory Louie ,
Alexandra Kueider-Paisley ,
M. Arthur Moseley ,
J. Will Thompson ,
Lisa St John Williams ,
Jessica D. Tenenbaum ,
Colette Blach ,
Rebecca Baillie ,
Xianlin Han ,
Sudeepa Bhattacharyya ,
Jon B. Toledo ,
Simon Schafferer ,
Sebastian Klein ,
Therese Koal ,
Shannon L. Risacher ,
Mitchel Allan Kling ,
Alison Motsinger-Reif ,
Daniel M. Rotroff ,
John Jack ,
Thomas Hankemeier ,
David A. Bennett ,
Philip L. De Jager ,
John Q. Trojanowski ,
Leslie M. Shaw ,
Michael W. Weiner ,
P. Murali Doraiswamy ,
Cornelia M. van Duijn ,
Andrew J. Saykin ,
Gabi Kastenmüller ,
Rima Kaddurah-Daouk
October 2018
October 2018
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Abstract
Increasing evidence suggests a role for the gut microbiome in central nervous system
disorders and a specific role for the gut-brain axis in neurodegeneration. Bile acids
(BAs), products of cholesterol metabolism and clearance, are produced in the liver
and are further metabolized by gut bacteria. They have major regulatory and signaling
functions and seem dysregulated in Alzheimer's disease (AD).