Psyllium ( Plantago Ovata  Forsk) Husk Powder as a Natural Superdisintegrant for Orodispersible Formulations: A Study on Meloxicam Tablets

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Abstract

(1) Background: In this work, we investigated the application of a natural superdisintegrant, psyllium ( Plantago ovata Forsk) husk powder, for the manufacture of orodispersible meloxicam tablets. Meloxicam was chosen as a model compound for the study. (2) Methods: The tablets were prepared using different concentrations of psyllium husk by direct compression. Bulk density, tapped density, hardness, friability, in vitro disintegration, and dissolution time tests were used to assess the quality of the formulations. (3) Results: Psyllium husk powder significantly increased the dissolution rate of meloxicam. The formulation containing 16 mg of psyllium husk powder showed the lowest wetting time, the highest water absorption ratio, and the lowest disintegration time compared to the control and to the other formulations. These effects may be attributed to the rapid uptake of water due to the vigorous swelling ability of psyllium husk powder. (4) Conclusions: The powder could be recommended as an effective natural superdisintegrant for orodispersible formulations.

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Orodispersible drug formulations for children and elderly

Marta Slavkova, Jörg Breitkreutz (2015)

Various orodispersible drug formulations have been recently introduced into the market. Oral lyophilisates and orodispersible granules, tablets or films have enriched the therapeutic options. In particular, the paediatric and geriatric population may profit from the advantages like convenient administration, lack of swallowing, ease of use. Until now, only a few novel products made it to the market as the development and production usually is more expensive than for conventional oral drug dosage forms like tablets or capsules. The review reports the recent advances, existing and upcoming products, and the significance of formulating patient-friendly oral dosage forms. The preparation of the medicines can be performed both in pharmaceutical industry and in community pharmacies. Recent advances, e.g. drug printing technologies, may facilitate this process for community or hospital pharmacies. Still, regulatory guidelines and pharmacopoeial monographs lack appropriate methods, specifications and global harmonization to foster the development of innovative orodispersible drug dosage forms.

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Multi-layer mucilage of Plantago ovata seeds: Rheological differences arise from variations in arabinoxylan side chains.

Long Yu, Gleb E. Yakubov, Wei Zeng … (2017)

Mucilages are hydrocolloid solutions produced by plants for a variety of functions, including the creation of a water-holding barrier around seeds. Here we report our discovery of the formation of three distinct mucilage layers around Plantago ovata seeds upon their hydration. Each layer is dominated by different arabinoxylans (AXs). These AXs are unusual because they are highly branched and contain β-1,3-linked xylose in their side chains. We show that these AXs have similar monosaccharide and linkage composition, but vary in their polymer conformation. They also exhibit distinct rheological properties in aqueous solution, despite analytical techniques including NMR showing little difference between them. Using enzymatic hydrolysis and chaotropic solvents, we reveal that hydrogen bonding and side chain distribution are key factors underpinning the distinct rheological properties of these complex AXs.

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Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics.

Roger T. Mulder, Heidi M Mansour, Jesse McLean … (2007)

The performance of dry powder aerosols for the delivery of drugs to the lungs has been studied extensively in the last decade. The focus for different research groups has been on aspects of the powder formulation, which relate to solid state, surface and interfacial chemistry, bulk properties (static and dynamic) and measures of performance. The nature of studies in this field, tend to be complex and correlations between specific properties and performance seem to be rare. Consequently, the adoption of formulation approaches that on a predictive basis lead to desirable performance has been an elusive goal but one that many agree is worth striving towards. The purpose of this paper is to initiate a discussion of the use of a variety of techniques to elucidate dry particle behavior that might guide the data collection process. If the many researchers in this field can agree on this, or an alternative, guide then a database can be constructed that would allow predictive models to be developed. This is the first of two papers that discuss static and dynamic methods of characterizing dry powder inhaler formulations. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association.

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Author and article information

Contributors

John O’Doherty: Role: Academic Editor

Marco Garcia-Vaquero: Role: Academic Editor

Gaurav Rajauria: Role: Academic Editor

Journal

Journal ID (nlm-ta): Molecules

Journal ID (iso-abbrev): Molecules

Journal ID (publisher-id): molecules

Title: Molecules

Publisher: MDPI

ISSN (Electronic): 1420-3049

Publication date (Electronic): 06 September 2019

Publication date Collection: September 2019

Volume: 24

Issue: 18

Electronic Location Identifier: 3255

Affiliations

[1 ]Department of Drug Technology and Social Pharmacy, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Kaunas 50161, Lithuania

[2 ]Institute of Pharmaceutical Technologies, Faculty of Pharmacy, Medical Academy, Lithuanian University of Health Sciences, Kaunas 50161, Lithuania

[3 ]Institute of Physiology and Pharmacology, Medical Academy, Lithuanian University of Health Sciences, Kaunas 50161, Lithuania

Author notes

[* ]Correspondence: Jurga.Bernatoniene@ 123456lsmuni.lt ; Tel.: +370-600-63349

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Jurga Bernatoniene https://orcid.org/0000-0003-1744-2932

Article

Publisher ID: molecules-24-03255

DOI: 10.3390/molecules24183255

PMC ID: 6766968

PubMed ID: 31500129

SO-VID: c434a3f3-1814-43ff-a0b1-edbd5b98974b

License:

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

Psyllium ( Plantago Ovata Forsk) Husk Powder as a Natural Superdisintegrant for Orodispersible Formulations: A Study on Meloxicam Tablets

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Most cited references 31

Orodispersible drug formulations for children and elderly

Multi-layer mucilage of Plantago ovata seeds: Rheological differences arise from variations in arabinoxylan side chains.

Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics.

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