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      A Case of Lichen Sclerosus et Atrophicus Accompanying Bullous Morphea

      case-report

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          Abstract

          Bullous morphea is a rare form of morphea characterized with bullae on or around atrophic morphea plaques. Whereas lichen sclerosus et atrophicus (LSA) is a disease the etiology of which is not fully known, and which is characterized with sclerosis. Coexistence of morphea and LSA has been identified in some cases. Some authors believe that these two diseases are different manifestations which are on the same spectrum. The 70-year-old patient stated herein, presented to us for 6 months with annular, atrophic plaques, ivory color in the middle, surrounded by living erythema, on the front and back of the trunk. Occasionally bulla formation on the plaques on the trunk lateral was identified. Fibrotic and atrophic plaques of ligneous hardness were present on the front side of tibia of both legs. In the histopathologic examination, the lesions were found concordant with bullous morphea and LSA. With colchicine 1.5 mg/day, pentoxifylline 1,200 mg/day, topical calcipotriol ointment and clobetasol propionate cream, the erythema in the patient's lesions faded and softening in the fibrotic plaques was observed. Concomitance of bullous morphea and LSA is a rarely seen, interesting coexistence which suggests a common, as yet unknown, underlying pathogenesis.

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          Most cited references22

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          Histopathology of the skin

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            Bullous morphea: clinical, pathologic, and immunopathologic evaluation of thirteen cases.

            Bullous morphea is a rare disease. Its pathogenesis is unknown. We evaluated bullous morphea clinically, pathologically, and immunopathologically and investigated the role of spirochetes and eosinophils in its pathogenesis. The clinical and pathologic findings from 13 patients with bullous morphea were reviewed. Tissue sections were studied with the Elias-Bosma stain for spirochetes and indirect immunofluorescence for eosinophil granule major basic protein. Bullae were found in all forms of morphea; the lower extremities were the most common sites of involvement. Lymphatic dilatation was found in 77% of the patients. Deposition of major basic protein was found in 60% of cases studied. There was no evidence of spirochetes in any of the specimens examined with the Elias-Bosma stain. Our results suggest that the pathogenesis of bullous morphea is related to lymphatic dilatation as well as release of major basic protein from eosinophils in some patients. We found no association between spirochetes and bullous morphea.
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              Coexistence of generalized morphea with hisotological changes in lichen sclerosus et atrophicus and lichen planus.

              We reported a 44-year-old Japanese woman with generalized multiple sclerotic plaques, which showed histological findings of morphea. This patient also had an erosive lesion on her mouth; its histological findings were consistent with lichen planus. A sclerotic lesion on her thigh showed the histological findings of lichen sclerosus et atrophicus (LSA). These data suggest that similar etiologic events or closely related pathologic processes are involved in morphea, lichen planus, and LSA.
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                Author and article information

                Journal
                Ann Dermatol
                AD
                Annals of Dermatology
                Korean Dermatological Association; The Korean Society for Investigative Dermatology
                1013-9087
                2005-3894
                December 2011
                27 December 2011
                : 23
                : Suppl 3
                : S354-S359
                Affiliations
                Department of Dermatology, Haydarpaş Numune Training and Research Hospital, Istansbul, Turkey.
                [1 ]Department of Pathology, Haydarpaş Numune Training and Research Hospital, Istansbul, Turkey.
                Author notes
                Corresponding author: Ceyda Tanzer Mumcuoglu, M.D., Haydarpaşa Numune Eğitim ve Araştırma Hastanesi Dermatoloji Kliniği Üsküdar, İstanbul, Turkey [34746]. Tel: 902164144502, Fax: 902164144502, ceydatanzer@ 123456gmail.com
                Article
                10.5021/ad.2011.23.S3.S354
                3276796
                22346277
                c3176c35-413e-4693-8744-8137b4394ca2
                Copyright © 2011 Korean Dermatological Association; The Korean Society for Investigative Dermatology

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 14 April 2010
                : 08 May 2011
                : 09 May 2011
                Categories
                Case Report

                Dermatology
                localised,scleroderma,lichen sclerosus et atroficus
                Dermatology
                localised, scleroderma, lichen sclerosus et atroficus

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