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      Intra‐Articular Injectable Biomaterials for Cartilage Repair and Regeneration

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          Abstract

          Osteoarthritis is a degenerative joint disease characterized by cartilage deterioration and subsequent inflammatory changes in the underlying bone. Injectable hydrogels have emerged as a promising approach for controlled drug delivery in cartilage therapies. This review focuses on the latest developments in utilizing injectable hydrogels as vehicles for targeted drug delivery to promote cartilage repair and regeneration. The pathogenesis of osteoarthritis is discussed to provide a comprehensive understanding of the disease progression. Subsequently, the various types of injectable hydrogels used for intra‐articular delivery are discussed. Specifically, physically and chemically crosslinked injectable hydrogels are critically analyzed, with an emphasis on their fabrication strategies and their capacity to encapsulate and release therapeutic agents in a controlled manner. Furthermore, the potential of incorporating growth factors, anti‐inflammatory drugs, and cells within these injectable hydrogels are discussed. Overall, this review offers a comprehensive guide to navigating the landscape of hydrogel‐based therapeutics in osteoarthritis.

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          The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

          Piotr Wojdasiewicz, Łukasz Poniatowski, Dariusz Szukiewicz (2014)
          Osteoarthritis (OA) is the most common chronic disease of human joints. The basis of pathologic changes involves all the tissues forming the joint; already, at an early stage, it has the nature of inflammation with varying degrees of severity. An analysis of the complex relationships indicates that the processes taking place inside the joint are not merely a set that (seemingly) only includes catabolic effects. Apart from them, anti-inflammatory anabolic processes also occur continually. These phenomena are driven by various mediators, of which the key role is attributed to the interactions within the cytokine network. The most important group controlling the disease seems to be inflammatory cytokines, including IL-1 β , TNF α , IL-6, IL-15, IL-17, and IL-18. The second group with antagonistic effect is formed by cytokines known as anti-inflammatory cytokines such as IL-4, IL-10, and IL-13. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of OA with respect to inter- and intracellular signaling pathways is still under investigation. This paper summarizes the current state of knowledge. The cytokine network in OA is put in the context of cells involved in this degenerative joint disease. The possibilities for further implementation of new therapeutic strategies in OA are also pointed.
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            Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications

            M. Reist, J. Berger, J.M. Mayer … (2004)
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              The extracellular matrix: Tools and insights for the "omics" era.

              Alexandra Naba, Karl R Clauser, Huiming Ding … (2016)
              The extracellular matrix (ECM) is a fundamental component of multicellular organisms that provides mechanical and chemical cues that orchestrate cellular and tissue organization and functions. Degradation, hyperproduction or alteration of the composition of the ECM cause or accompany numerous pathologies. Thus, a better characterization of ECM composition, metabolism, and biology can lead to the identification of novel prognostic and diagnostic markers and therapeutic opportunities. The development over the last few years of high-throughput ("omics") approaches has considerably accelerated the pace of discovery in life sciences. In this review, we describe new bioinformatic tools and experimental strategies for ECM research, and illustrate how these tools and approaches can be exploited to provide novel insights in our understanding of ECM biology. We also introduce a web platform "the matrisome project" and the database MatrisomeDB that compiles in silico and in vivo data on the matrisome, defined as the ensemble of genes encoding ECM and ECM-associated proteins. Finally, we present a first draft of an ECM atlas built by compiling proteomics data on the ECM composition of 14 different tissues and tumor types.
              Article 0 comments Cited 280 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Akhilesh K. Gaharwar: (View ORCID Profile)
                Journal
                Title: Advanced Healthcare Materials
                Abbreviated Title: Adv Healthcare Materials
                Publisher: Wiley
                ISSN (Print): 2192-2640
                ISSN (Electronic): 2192-2659
                Publication date (Electronic): April 08 2024
                Affiliations
                [1 ] Department of Biomedical Engineering College of Engineering Texas A&M University College Station TX 77843 USA
                [2 ] Department of Veterinary Integrative Biosciences School of Veterinary Medicine and Biomedical Sciences Texas A&M University College Station TX 77843 USA
                [3 ] Department of Material Science and Engineering College of Engineering Texas A&M University College Station TX 77843 USA
                [4 ] Genetics and Genomics Interdisciplinary Program Texas A&M University College Station TX 77843 USA
                Article
                DOI: 10.1002/adhm.202303794
                PubMed ID: 38324655
                SO-VID: c295bcdd-4a1e-46e5-8bc9-5a16777945ce
                Copyright © © 2024
                License:

                http://creativecommons.org/licenses/by-nc/4.0/

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