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      New classifications for quantum bioinformatics: Q-bioinformatics, QCt-bioinformatics, QCg-bioinformatics, and QCr-bioinformatics

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          Abstract

          Bioinformatics has revolutionized biology and medicine by using computational methods to analyze and interpret biological data. Quantum mechanics has recently emerged as a promising tool for the analysis of biological systems, leading to the development of quantum bioinformatics. This new field employs the principles of quantum mechanics, quantum algorithms, and quantum computing to solve complex problems in molecular biology, drug design, and protein folding. However, the intersection of bioinformatics, biology, and quantum mechanics presents unique challenges. One significant challenge is the possibility of confusion among scientists between quantum bioinformatics and quantum biology, which have similar goals and concepts. Additionally, the diverse calculations in each field make it difficult to establish boundaries and identify purely quantum effects from other factors that may affect biological processes. This review provides an overview of the concepts of quantum biology and quantum mechanics and their intersection in quantum bioinformatics. We examine the challenges and unique features of this field and propose a classification of quantum bioinformatics to promote interdisciplinary collaboration and accelerate progress. By unlocking the full potential of quantum bioinformatics, this review aims to contribute to our understanding of quantum mechanics in biological systems.

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          Most cited references166

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          Quantum sensing

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            Natural engineering principles of electron tunnelling in biological oxidation-reduction.

            We have surveyed proteins with known atomic structure whose function involves electron transfer; in these, electrons can travel up to 14 A between redox centres through the protein medium. Transfer over longer distances always involves a chain of cofactors. This redox centre proximity alone is sufficient to allow tunnelling of electrons at rates far faster than the substrate redox reactions it supports. Consequently, there has been no necessity for proteins to evolve optimized routes between redox centres. Instead, simple geometry enables rapid tunnelling to high-energy intermediate states. This greatly simplifies any analysis of redox protein mechanisms and challenges the need to postulate mechanisms of superexchange through redox centres or the maintenance of charge neutrality when investigating electron-transfer reactions. Such tunnelling also allows sequential electron transfer in catalytic sites to surmount radical transition states without involving the movement of hydride ions, as is generally assumed. The 14 A or less spacing of redox centres provides highly robust engineering for electron transfer, and may reflect selection against designs that have proved more vulnerable to mutations during the course of evolution.
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              Quantum biology

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                Author and article information

                Contributors
                Journal
                Brief Bioinform
                Brief Bioinform
                bib
                Briefings in Bioinformatics
                Oxford University Press
                1467-5463
                1477-4054
                March 2024
                05 March 2024
                05 March 2024
                : 25
                : 2
                : bbae074
                Affiliations
                Department of Bioinformatics , Kish International Campus, University of Tehran , Kish Island, Iran
                Department of Bioinformatics , Kish International Campus, University of Tehran , Kish Island, Iran
                Duke Molecular Physiology Institute, Duke University School of Medicine-Cardiology , Durham, NC, 27701, USA
                Department of Fisheries , Faculty of Natural Resources, University of Tehran , Karaj, Iran
                Cancer Research Center, Shahid Beheshti University of Medical Sciences , Tehran, Iran
                Department of Bioinformatics , Kish International Campus, University of Tehran , Kish Island, Iran
                Author notes
                Corresponding author. Majid Mokhtari, Ph.D. Department of Bioinformatics Kish International Campus, University of Tehran, Kish Island, Iran. E-mail: majid.mokhtari@ 123456ut.ac.ir
                Author information
                https://orcid.org/0000-0002-0927-6420
                Article
                bbae074
                10.1093/bib/bbae074
                10939336
                38446742
                c1bc005d-bf3d-4c56-9171-b8ab49c48b9f
                © The Author(s) 2024. Published by Oxford University Press.

                This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 21 July 2023
                : 14 November 2023
                : 7 February 2021
                Page count
                Pages: 18
                Categories
                Review
                AcademicSubjects/SCI01060

                Bioinformatics & Computational biology
                quantum mechanics,quantum biology,quantum bioinformatics

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