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      Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens.

      Bioorganic & Medicinal Chemistry
      Animals, COS Cells, Cercopithecus aethiops, Flavonoids, isolation & purification, pharmacology, Humans, Magnetic Resonance Spectroscopy, Mass Spectrometry, Plant Roots, chemistry, Plasmids, genetics, Reverse Transcriptase Polymerase Chain Reaction, Sodium-Glucose Transporter 1, antagonists & inhibitors, Sodium-Glucose Transporter 2, Sophora, Spectrometry, Mass, Electrospray Ionization

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          Abstract

          The methanol extract of Sophora flavescens, which is used in traditional Chinese medicine (sophorae radix), showed potent Na(+)-glucose cotransporter (SGLT) inhibitory activity. Our search for active components identified many well-known flavonoid antioxidants: kurarinone, sophoraflavanone G, kushenol K, and kushenol N.

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