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      Catheter ablation for ventricular tachycardia in patients with cardiac sarcoidosis: a systematic review

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          Abstract

          Cardiac sarcoidosis (CS) is associated with a poor prognosis. Important features of CS include heart failure, conduction abnormalities, and ventricular arrhythmias. Ventricular tachycardia (VT) is often refractory to antiarrhythmic drugs (AAD) and immunosuppression. Catheter ablation has emerged as a treatment option for recurrent VT. However, data on the efficacy and outcomes of VT ablation in this context are sparse.

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          Cardiac sarcoidosis: epidemiology, characteristics, and outcome over 25 years in a nationwide study.

          Kari Kaikkonen, Markus Pelkonen, Jorma O. Kokkonen … (2015)
          This study was designed to assess the epidemiology, characteristics, and outcome of cardiac sarcoidosis (CS) in Finland.
          Article 0 comments Cited 157 times – based on 0 reviews     Review now
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            Cardiac sarcoidosis: a comprehensive review

            Vishal Sekhri, Shireen Sanal, Lawrence DeLorenzo … (2011)
            Sarcoidosis is a multisystem granulomatous disease of unknown etiology characterized by noncaseating granulomas in involved organs. Organs involved with sarcoidosis include lymph nodes, skin, lung, central nervous system, and eye. Only 40-50% of patients with cardiac sarcoidosis diagnosed at autopsy have the diagnosis made during their lifetime. Cardiac sarcoidosis can manifest itself as complete heart block, ventricular arrhythmias, congestive heart failure, pericardial effusion, pulmonary hypertension, and ventricular aneurysms. Diagnostic tests such as the electrocardiogram, two-dimensional echocardiography, cardiac magnetic resonance imaging, positron emission tomography scan, radionuclide scan, and endomyocardial biopsy can be helpful in the early detection of cardiac sarcoidosis. Considering the increased risk of sudden death, cardiac sarcoidosis is an indication for early treatment with corticosteroids or other immunosuppressive agents. Other treatments include placement of a pacemaker or implantable defibrillator to prevent sudden death. In refractory cases, cardiac transplantation should be considered.
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              Cardiac sarcoidosis.

              Jessica S. Kim, Marc Judson, Robert Donnino … (2009)
              Cardiac sarcoidosis (CS) is a rare but potentially fatal condition that may present with a wide range of clinical manifestations including congestive heart failure, conduction abnormalities, and most notably, sudden death. Recent advances in imaging technology allow easier detection of CS, but the diagnostic guidelines with inclusion of these techniques have yet to be written. It has become clear that minimally symptomatic or asymptomatic cardiac involvement is far more prevalent than previously thought. Because of the potential life-threatening complications and potential benefit of treatment, all patients diagnosed with sarcoidosis should be screened for cardiac involvement. Patients with CS and symptoms such as syncope need an aggressive workup for a potentially life-threatening etiology, and often require implantable cardioverter-defibrillator therapy. CS patients without arrhythmic symptoms are still at risk for sudden death and may warrant an implantable cardioverter-defibrillator for primary prevention reasons. Although corticosteroids are regarded as the first-line drug of choice, therapy for CS is not yet standardized, and it is unclear at this point whether asymptomatic patients require therapy. Randomized clinical trials are clearly warranted to answer these very important patient care questions, and are endorsed fully by the authors.
              Article 0 comments Cited 65 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Title: EP Europace
                Publisher: Oxford University Press (OUP)
                ISSN (Print): 1099-5129
                ISSN (Electronic): 1532-2092
                Publication date Created: April 2018
                Publication date Created: April 01 2018
                Publication date Created: April 21 2017
                Publication date Other: April 2018
                Publication date (Print): April 01 2018
                Publication date (Electronic): April 21 2017
                Volume: 20
                Issue: 4
                Pages: 682-691
                Affiliations
                [1 ]Electrophysiology Department, Barts Heart Centre, St. Bartholomew’s Hospital, West Smithfield, London EC1A 7BE, UK
                [2 ]Institute of Cardiovascular Science, University College London, Gower St, London WC1E 6BT, UK
                [3 ]Cardiology Department, Royal Brompton Hospital, Sydney St, SW3 6NP, London, UK
                [4 ]Division of Electrophysiology, Department of Cardiovascular Medicine, University Hospital of Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany
                Article
                DOI: 10.1093/europace/eux077
                PubMed ID: 28444174
                SO-VID: bfddffc0-d016-4200-9320-da7e0a45094a
                Copyright © © 2017
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                http://academic.oup.com/journals/pages/about_us/legal/notices

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