Simultaneous determination of arbutin and its decomposed product hydroquinone in whitening creams using high-performance liquid chromatography with photodiode array detection: Effect of temperature and pH on decomposition.

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Abstract

Arbutin is an effective agent for the treatment of melanin disorders. Arbutin may be converted to hydroquinone under conditions of high temperature, ultraviolet (UV) radiation and dilute acid. The aim of the current study was to develop an analytical method to determine the levels of arbutin and hydroquinone in whitening cosmetic products using high-performance liquid chromatography with photodiode array detection (HPLC-DAD). In addition, we investigated the effects of high temperature and pH on the decomposition of arbutin.

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Journal

Journal ID (iso-abbrev): Int J Cosmet Sci

Title: International journal of cosmetic science

Publisher: Wiley

ISSN (Electronic): 1468-2494

ISSN (Print): 0142-5463

Publication date (Electronic): Dec 2015

Volume: 37

Issue: 6

Affiliations

[1 ] Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Konkuk University, Nuengdong-ro, Gwangjin-gu, Seoul, 143-701, Korea.

[2 ] Public Health Research Division, Gyeonggi Province Institute of Health and Environment, 95, Pajang cheon-ro, Jangan-gu, Suwonsi, Gyeonggi Province, 440-290, Korea.

[3 ] Biotechnology Research Institute, College of Agriculture and Life Sciences, Chonnam National University, 300 Yongbong-dong, Buk-gu, Gwangju, 500-757, Korea.

[4 ] Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.

Article

DOI: 10.1111/ics.12228

PubMed ID: 25857400

SO-VID: bedb78f4-df36-4ac3-b5f4-d4ea864600d5

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Keywords: arbutin,high-performance liquid chromatography,whitening cosmetics,hydroquinone,temperature

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Keywords: arbutin, high-performance liquid chromatography, whitening cosmetics, hydroquinone, temperature

Simultaneous determination of arbutin and its decomposed product hydroquinone in whitening creams using high-performance liquid chromatography with photodiode array detection: Effect of temperature and pH on decomposition.

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