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Abstract
Human schistosomiasis is associated with IgE and eosinophilia, feature of a type 2
response. In experimental investigations, murine model has been widely used in order
to dissect the immune responses involved in the expression of protective immunity
or disease in Schistosoma mansoni infection. Collectively, observations made in this
model and in humans demonstrated a strong contrast since a Th2 response in infected
mice is involved in the expression of pathology, however, in infected humans the same
type of response is rather beneficial for the host. This review will consider the
relevance of extrapolating studies of immune responses from experimentally infected
rats a semi-permissive host, to studies on S. mansoni infected humans.