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      Controlled released naringin-loaded liposome/sucrose acetate isobutyrate hybrid depot for osteogenesis in vitro and in vivo

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          Abstract

          Introduction: A common problem in bone tissue engineering is that the burst release of active osteogenic factors is not beneficial for osteogenesis. This study aimed to prepare naringin (Ng) liposomes to reduce the burst release of Ng and improve new bone formation.

          Methods: We synthesized Ng liposomes using the thin-film hydration method. Drug-encapsulation efficacy experiments were conducted using the ultracentrifugation technique. The morphology and size distributions of freezedried liposomes were determined by transmission electron microscopy and dynamic light scattering. The Ng liposomes and Ng-lipo/sucrose acetate isobutyrate (SAIB) depots were characterized using Fourier transform infrared spectroscopy and in vitro release studies. After implantation of the Ng-lipo/SAIB depots, in vitro osteoblast-liposome interactions and in vivo osteogenesis were tested.

          Results: The formulation of freeze-dried Ng liposomes via an optimized recipe yielded nanosized (136.9 nm) negatively charged particles with a high encapsulation efficiency (~76.3%). Their chemical structure did not change after adding SAIB to the Ng liposomes. The burst release was reduced dramatically from 74.4% to 23.7%. In vivo, after 8 weeks, the new bone formation rate in the calvarial defects of Sprague-Dawley rats receiving Ng-lipo/SAIB was 57% compared with 25.18% in the control group ( p = .0003).

          Discussion: Our results suggested that Ng-lipo/SAIB hybrid depots could serve as candidate materials for drug delivery in bone regeneration applications.

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          Most cited references54

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          Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems

          Lipid-based drug delivery systems, or lipidic carriers, are being extensively employed to enhance the bioavailability of poorly-soluble drugs. They have the ability to incorporate both lipophilic and hydrophilic molecules and protecting them against degradation in vitro and in vivo. There is a number of physical attributes of lipid-based nanocarriers that determine their safety, stability, efficacy, as well as their in vitro and in vivo behaviour. These include average particle size/diameter and the polydispersity index (PDI), which is an indication of their quality with respect to the size distribution. The suitability of nanocarrier formulations for a particular route of drug administration depends on their average diameter, PDI and size stability, among other parameters. Controlling and validating these parameters are of key importance for the effective clinical applications of nanocarrier formulations. This review highlights the significance of size and PDI in the successful design, formulation and development of nanosystems for pharmaceutical, nutraceutical and other applications. Liposomes, nanoliposomes, vesicular phospholipid gels, solid lipid nanoparticles, transfersomes and tocosomes are presented as frequently-used lipidic drug carriers. The advantages and limitations of a range of available analytical techniques used to characterize lipidic nanocarrier formulations are also covered.
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            A simple equation for description of solute release II. Fickian and anomalous release from swellable devices

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              Diffusion of univalent ions across the lamellae of swollen phospholipids.

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                Author and article information

                Contributors
                Journal
                Front Bioeng Biotechnol
                Front Bioeng Biotechnol
                Front. Bioeng. Biotechnol.
                Frontiers in Bioengineering and Biotechnology
                Frontiers Media S.A.
                2296-4185
                05 January 2023
                2022
                : 10
                : 1097178
                Affiliations
                [1] 1 Stomatological Hospital of Chongqing Medical University , Chongqing, China
                [2] 2 Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences , Chongqing, China
                [3] 3 Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education , Chongqing, China
                Author notes

                Edited by: Michele Iafisco, National Research Council (CNR), Italy

                Reviewed by: Ruchi Tiwari, Pranveer Singh Institute of Technology PSIT, India

                Stéphanie Andrade, University of Porto, Portugal

                Andang Miatmoko, Universitas Airlangga, Indonesia

                *Correspondence: Xiaohong Wu, 500222@ 123456hospital.cqmu.edu.cn

                This article was submitted to Nanobiotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology

                Article
                1097178
                10.3389/fbioe.2022.1097178
                9849584
                36686256
                b9ec1f01-5180-4150-8edb-8b034c7282ce
                Copyright © 2023 Meng, Song, Yi, Li, Zhang, Shu and Wu.

                This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

                History
                : 13 November 2022
                : 19 December 2022
                Funding
                Funded by: National Natural Science Foundation of China , doi 10.13039/501100001809;
                Categories
                Bioengineering and Biotechnology
                Original Research

                sucrose acetate isobutyrate,anionic liposomes,injectable,local drug delivery,controlled release

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