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      Comparison of the EUCAST-AFST broth dilution method with the CLSI reference broth dilution method (M38-A) for susceptibility testing of posaconazole and voriconazole against Aspergillus spp.

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          Abstract

          The susceptibilities of 40 clinical isolates of Aspergillus spp. (Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Aspergillus terreus) were determined for posaconazole and voriconazole by the CLSI M38-A and EUCAST-AFST broth dilution methods. Where a discrepancy was observed between the methods, the EUCAST method tended to give higher MIC values. Overall, the level of agreement was 92.5% and the intra-class correlation coefficient was > 0.90.

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          Author and article information

          Journal
          Clin. Microbiol. Infect.
          Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
          Wiley
          1198-743X
          1198-743X
          Sep 2006
          : 12
          : 9
          Affiliations
          [1 ] Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden. Erja.Chryssanthou@karolinska.se
          Article
          S1198-743X(14)64309-3
          10.1111/j.1469-0691.2006.01419.x
          16882296
          b8cb7a11-9786-445a-8e84-34aaffff8fef
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