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      Antimicrobial resistance pattern of Acinetobacter; a multicenter study, comparing European Committee on Antimicrobial Susceptibility Testing (EUCAST) and the Clinical and Laboratory Standards Institute (CLSI); evaluation of susceptibility testing methods for polymyxin

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          Abstract

          Introduction: Acinetobacter species in clinical isolates cause severe infections including meningitis, bloodstream infection, ventilator-associated pneumonia, and surgical site infections. Objectives: In the present study, we evaluated Acinetobacter drug resistance using both European Committee on Antimicrobial Susceptibility Testing (EUCAST) and the Clinical and Laboratory Standards Institute (CLSI) antimicrobial susceptibility test methods. Materials and Methods: Clinical specimens of 128 patients who were admitted in three referral tertiary care teaching hospitals were enrolled in 2014. Blood and other sterile fluid samples, endotracheal secretion, ulcer, urine and other clinical specimen cultures were included, and microbial resistance of Acinetobacter isolates was determined and compared with disk diffusion and E-test antimicrobial susceptibility methods, using both the EUCAST and CLSI standards. Cohen’s kappa coefficient was also reported. Results: The highest percentage of resistance (96.9%) was found for meropenem and imipenem antimicrobials, and the lowest resistance (82.8%) was found for amikacin. The highest kappa agreement coefficient was for ciprofloxacin (kappa coefficient = 0.783), and the lowest kappa was for amikacin (kappa coefficient = 0.21). Conclusion: According to the results, it is better to consider amikacin as a choice in combination with another effective antimicrobial for treatment of drug resistant Acinetobacter.

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          Contributors
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          Journal
          ipp
          Immunopathologia Persa
          Immunopathol Persa
          Maad Rayan Publishing Company
          2423-8015
          January 2021
          July 07 2020
          : 7
          : 1
          : e04
          Affiliations
          [1 ]Department of Infectious Diseases, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
          [2 ]Department of Pathology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
          [3 ]Department of Infectious Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
          [4 ]Bachelor of Laboratory Sciences, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
          [5 ]Department of Infectious Disease, School of Medicine, Antimicrobial Resistance Research Center, Immunology & Infectious Disease Research Institute, Shahid Motahari Burns Hospital, Iran University of Medical Sciences, Tehran, Iran
          Article
          10.34172/ipp.2021.04
          4d56f78e-c1a4-44af-a80c-d60f4c3780c7
          © 2020
          History

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