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      Arrhythmia and COVID-19 in children

      review-article
      , MD, PhD 1 , 2
      Clinical and Experimental Pediatrics
      Korean Pediatric Society
      COVID-19, MIS-C, SARS-CoV-2, Arrhythmia, Child

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          Abstract

          The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection caused worldwide health problems, and coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization in March 2020. Cardiovascular complications of COVID-19 are not uncommon; among them, arrhythmia is considered a significant risk factor for poor health outcomes in adults. However, data are scarce on the arrhythmia of pediatric patients with SARS-CoV-2 infection, possibly due to their mild symptoms and low incidence of cardiovascular involvement. Multisystem inflammatory syndrome in children reportedly features increased cardiovascular involvement, but arrhythmic complications remain unidentified. Thus, here we review the epidemiology, manifestations, and outcomes of pediatric arrhythmia associated with COVID-19.

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          Most cited references89

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          Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

          In December 2019, novel coronavirus (2019-nCoV)-infected pneumonia (NCIP) occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of affected patients is limited.
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            Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19)

            This case series study evaluates the association of underlying cardiovascular disease and myocardial injury on fatal outcomes in patients with coronavirus disease 2019 (COVID-19).
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              SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

              We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells' potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
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                Author and article information

                Journal
                Clin Exp Pediatr
                Clin Exp Pediatr
                CEP
                Clinical and Experimental Pediatrics
                Korean Pediatric Society
                2713-4148
                May 2023
                18 April 2023
                : 66
                : 5
                : 190-200
                Affiliations
                [1 ]Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Korea
                [2 ]Brown University, Providence, RI, USA
                Author notes
                Corresponding author: Mi Kyoung Song, MD, PhD. Department of Pediatrics, Division of Pediatric Cardiology, Seoul National University Children’s Hospital, Seoul National University College of Medicine, 101 Daehak-Ro, Jongno-gu, Seoul 03080, Korea Email: mksong00@ 123456snu.ac.kr
                Author information
                http://orcid.org/0000-0002-0529-869X
                http://orcid.org/0000-0002-1226-1107
                Article
                cep-2023-00024
                10.3345/cep.2023.00024
                10167409
                37070296
                b8319dc2-2f26-495f-90e2-5c803b8db9dd
                Copyright © 2023 by The Korean Pediatric Society

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 3 January 2023
                : 4 February 2023
                : 6 February 2023
                Categories
                Review Article
                Cardiology

                covid-19,mis-c,sars-cov-2,arrhythmia,child
                covid-19, mis-c, sars-cov-2, arrhythmia, child

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