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      Comment to "Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis"

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          Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.

          Sepsis - which is a severe life-threatening infection with organ dysfunction - initiates a complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be considered a race to the death between the pathogens and the host immune system, and it is the proper balance between the often competing pro- and anti-inflammatory pathways that determines the fate of the individual. Although the field of sepsis research has witnessed the failure of many highly touted clinical trials, a better understanding of the pathophysiological basis of the disorder and the mechanisms responsible for the associated pro- and anti-inflammatory responses provides a novel approach for treating this highly lethal condition. Biomarker-guided immunotherapy that is administered to patients at the proper immune phase of sepsis is potentially a major advance in the treatment of sepsis and in the field of infectious disease.
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            Definitions of Cytomegalovirus Infection and Disease in Transplant Patients for Use in Clinical Trials.

            Cytomegalovirus (CMV) infection and disease are important causes of morbidity and mortality in transplant recipients. For the purpose of developing consistent reporting of CMV outcomes in clinical trials, definitions of CMV infection and disease were developed and most recently published in 2002. Since then, there have been major developments in its diagnosis and management. Therefore, the CMV Drug Development Forum consisting of scientists, clinicians, regulators, and industry representatives has produced an updated version incorporating recent knowledge with the aim to support clinical research and drug development. The main changes compared to previous definitions are the introduction of a "probable disease" category and to incorporate quantitative nucleic acid testing in some end-organ disease categories. As the field evolves, the need for updates of these definitions is clear, and collaborative efforts between scientists, regulators, and industry can provide a platform for this work.
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              Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial.

              The role of cytomegalovirus (CMV) reactivation in mediating adverse clinical outcomes in nonimmunosuppressed adults with critical illness is unknown.
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                Author and article information

                Contributors
                dryiminli@vip.163.com
                lxq1118@126.com
                Journal
                Crit Care
                Critical Care
                BioMed Central (London )
                1364-8535
                1466-609X
                28 May 2024
                28 May 2024
                2024
                : 28
                : 182
                Affiliations
                [1 ]GRID grid.470124.4, Department of Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, , The First Affiliated Hospital of Guangzhou Medical University, ; Guangzhou, Guangdong People’s Republic of China
                [2 ]Guangzhou Medical University, ( https://ror.org/00zat6v61) Guangzhou, Guangdong People’s Republic of China
                Article
                4914
                10.1186/s13054-024-04914-2
                11134663
                38807185
                b545171f-72cd-4bf4-bb07-a95f74f60a63
                © The Author(s) 2024

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

                History
                : 12 April 2024
                : 13 April 2024
                Funding
                Funded by: Science and Technology Program of Guangzhou
                Award ID: SL2023A04J00179
                Award ID: 2024A04J3312
                Award Recipient :
                Funded by: Guangzhou Medical University Students Extracurricular Academic Technology Project
                Award ID: 2022A006
                Award ID: 2022B004
                Award Recipient :
                Funded by: the National Natural Science Foundation of China
                Award ID: 82070084
                Award Recipient :
                Categories
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                © BioMed Central Ltd., part of Springer Nature 2024

                Emergency medicine & Trauma
                Emergency medicine & Trauma

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